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Aquí, allí y en todas partes: la importancia de los sitios de contacto de la membrana ER

Haoxi Wu¹, Pedro Carvalho², Gia K Voeltz³

¹Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309, USA.

Science (New York, N.Y.)

|August 4, 2018

Resumen

Los orgánulos se comunican a través de los sitios de contacto de la membrana (MCS), no como compartimentos aislados. El retículo endoplasmático (ER) regula dinámicamente las funciones celulares a través de estos MCS cruciales con otros orgánulos y la membrana plasmática.

Área de la Ciencia:

Biología celular
Biología molecular

Sus antecedentes:

Tradicionalmente, los orgánulos fueron vistos como compartimentos celulares discretos.
La evidencia emergente destaca la interdependencia y la comunicación entre los orgánulos.

Objetivo del estudio:

Explorar el papel de los sitios de contacto de la membrana (MCS) en la comunicación de los orgánulos.
Centrarse en la participación del retículo endoplasmático (ER) en el MCS y la regulación celular.

Principales métodos:

Revisión de la literatura actual sobre las interacciones de los orgánulos y las MCS.
Centrarse en los estudios que investigan las EMC asociadas a ER.

Principales resultados:

Los orgánulos funcionan como estructuras interdependientes que se comunican a través de MCS.
Las MCS facilitan las funciones celulares vitales como la transferencia de lípidos e iones, la señalización y la división de orgánulos.
El retículo endoplasmático (ER) forma MCS con numerosos orgánulos y la membrana plasmática.

Conclusiones:

La red ER dinámica es fundamental para la regulación celular a través de los MCS.
La comprensión de las MCS remodela nuestra visión de la compartimentación y la función celular.

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