Video Experimental Relacionado
Updated: Feb 6, 2026
07:54
A Method to Assess Bacteriocin Effects on the Gut Microbiota of Mice
Published on: July 25, 2017
14.7K
La selección neonatal por el receptor tipo Toll 5 influye en la composición de la microbiota intestinal a largo plazo
Marcus Fulde1,2, Felix Sommer3,4, Benoit Chassaing5,6
1Institute for Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Hannover, Germany.
Nature
|August 10, 2018
Resumen
La inmunidad intestinal neonatal da forma a la composición de la microbiota durante toda la vida. La expresión temprana del receptor Toll-like 5 (TLR5) en ratones controla la colonización bacteriana, lo que influye en la homeostasis inmune y la salud de los adultos.
Área de la Ciencia:
- Microbiología
- Inmunología
- Biología del desarrollo
Sus antecedentes:
- Las alteraciones en la microbiota intestinal están relacionadas con enfermedades inmunomediadas y metabólicas.
- El período postnatal es crucial para el desarrollo de las interacciones huésped-microbio y el equilibrio inmune.
- Los mecanismos moleculares que rigen el establecimiento de la microbiota neonatal siguen sin estar claros.
Objetivo del estudio:
- Identificar los circuitos reguladores mediados por el huésped que controlan la colonización bacteriana neonatal.
- Definir los mecanismos moleculares que influyen en la composición de la microbiota durante toda la vida.
- Investigar el papel del receptor tipo Toll 5 (TLR5) en la inmunidad intestinal temprana.
Principales métodos:
- Análisis de la expresión dependiente de la edad de TLR5 en el epitelio intestinal neonatal de ratón.
- Experimentos de colonización competitivos para evaluar el control bacteriano mediado por TLR5.
- Experimentos de transferencia de microbiota en ratones libres de gérmenes (neonatales/adultos, de tipo salvaje/deficiente en Tlr5).
Principales resultados:
- Se ha demostrado la expresión dependiente de la edad de TLR5 en el intestino de ratones neonatales.
- Se ha demostrado que la producción de REG3γ mediada por TLR5 es crítica para limitar la colonización bacteriana flagelada.
- Se reveló que la expresión neonatal de TLR5 tiene un impacto significativo en la composición de la microbiota adulta.
Conclusiones:
- Un circuito regulador mediado por el huésped que involucra a TLR5 actúa durante la vida neonatal temprana para dar forma a la microbiota de por vida.
- La inmunización neonatal por TLR5 influye en el establecimiento de una microbiota adulta beneficiosa.
- Los factores ambientales tempranos que interrumpen el establecimiento de la microbiota pueden afectar la salud inmune del adulto.
Videos de Conceptos Relacionados
01:27Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists
681
5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
681
01:05Long-term Depression
33.3K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
33.3K
03:35Classifying Matter by Composition
90.7K
Matter: Pure Substances and Mixtures
According to its composition, the matter can be classified into two broad categories — pure substances and mixtures.
A pure substance is a form of matter that has a constant composition throughout with uniform properties. For example, any sample of sucrose has the same composition and same physical properties, such as melting point, color, and sweetness, regardless of the source from which it is isolated.
A mixture is composed of two or...
According to its composition, the matter can be classified into two broad categories — pure substances and mixtures.
A pure substance is a form of matter that has a constant composition throughout with uniform properties. For example, any sample of sucrose has the same composition and same physical properties, such as melting point, color, and sweetness, regardless of the source from which it is isolated.
A mixture is composed of two or...
90.7K
01:045-Number Summary
5.7K
In a dataset, the 5-number summary includes the minimum data value, the data value of the first quartile, the median data value or data value of the second quartile, the data value of the third quartile, and the maximum data value. These 5 data values can be visualized as a box and whisker plot.
In a box plot, the minimum and maximum data values represent the lower and upper whiskers in the graph, and the median is designated as the center of the box in the chart. The first quartile and third...
In a box plot, the minimum and maximum data values represent the lower and upper whiskers in the graph, and the median is designated as the center of the box in the chart. The first quartile and third...
5.7K
01:21Frequency-dependent Selection
24.1K
When the fitness of a trait is influenced by how common it is (i.e., its frequency) relative to different traits within a population, this is referred to as frequency-dependent selection. Frequency-dependent selection may occur between species or within a single species. This type of selection can either be positive—with more common phenotypes having higher fitness—or negative, with rarer phenotypes conferring increased fitness.
24.1K
01:31Internal Receptors
74.7K
Many cellular signals are hydrophilic and therefore cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind to internal, or intracellular, receptors that reside within the cell. Many mammalian steroid hormones use this mechanism of cell signaling, as does nitric oxide (NO) gas.
74.7K