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La apoptosis se propaga a través del citoplasma como ondas desencadenantes
Xianrui Cheng1, James E Ferrell2,3
1Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305-5174, USA.
Science (New York, N.Y.)
|August 11, 2018
Resumen
La muerte celular programada, o apoptosis, se propaga a través de ondas desencadenantes auto-regeneradas en extractos y células de huevo de Xenopus. Estas ondas, que viajan a ~ 30 micrómetros por minuto, son cruciales para la señalización celular y la homeostasis de los tejidos.
Área de la Ciencia:
- Biología celular
- Biología del desarrollo
- La bioquímica
Sus antecedentes:
- La apoptosis es la muerte celular programada esencial para el desarrollo y la homeostasis de los animales.
- La red apoptótica puede incluir bucles de retroalimentación positiva que permiten las ondas gatillo auto-regeneradas.
- Comprender estos mecanismos es clave para la señalización celular.
Objetivo del estudio:
- Investigar si la apoptosis se propaga a través de ondas desencadenantes en extractos libres de células y células intactas.
- Identificar los componentes moleculares y los circuitos de retroalimentación involucrados en la propagación de ondas.
- Para determinar la velocidad y las características de estas ondas apoptóticas.
Principales métodos:
- Experimentos con extractos de huevo de Xenopus laevis sin células.
- Estudios de fraccionamiento y de inhibidores para identificar los componentes clave.
- Observación de las ondas superficiales en ovocitos y óvulos apoptóticos.
- Análisis de correlación con la activación de la caspasa.
Principales resultados:
- Se observaron ondas desencadenantes apoptóticas en extractos de huevo de Xenopus a velocidades de ~ 30 micrómetros por minuto.
- Se implicaron múltiples bucles de retroalimentación en la generación de ondas.
- Los ovocitos y huevos intactos de Xenopus mostraron ondas superficiales correlacionadas y activación de la caspasa a velocidades similares.
- Se demostró que la apoptosis se propaga a través de ondas desencadenantes en ambos sistemas.
Conclusiones:
- La apoptosis se propaga a través de ondas desencadenantes auto-regeneradas en extractos libres de células y células intactas.
- Estas ondas son críticas para propagar la apoptosis a través de distancias dentro de las células.
- Las ondas de activación representan un mecanismo fundamental en la señalización celular y los procesos biológicos.
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