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La enterobactina siderófora microbiana promueve la absorción de hierro mitocondrial y el desarrollo del huésped a

Bin Qi¹, Min Han¹

¹Howard Hughes Medical Institute and Department of MCDB of University of Colorado at Boulder, Boulder, CO 80309, USA.

|August 28, 2018

Resumen

La enterobactina (Ent) producida por bacterias apoya sorprendentemente el crecimiento del huésped al aumentar la absorción de hierro mitocondrial en C. elegans y células de mamíferos. Este hallazgo revela un nuevo mecanismo de hospedaje para utilizar moléculas bacterianas.

Área de la Ciencia:

Microbiología
Biología molecular
Interacciones huésped-micróbio

Sus antecedentes:

Comprender la simbiosis huésped-microbio requiere aclarar las funciones de las moléculas microbianas.
La enterobactina (Ent), un sideróforo bacteriano, es abundante en el intestino, pero sus efectos en el huésped se debaten.
Un beneficio potencial del huésped de Ent sugiere mecanismos de utilización no caracterizados.

Objetivo del estudio:

Investigar el papel de la enterobactina (Ent) en la fisiología del huésped.
Para identificar los mecanismos de acogida para la utilización de Ent.
Para explorar el impacto de Ent en el hierro mitocondrial.

Principales métodos:

Utilizó C. elegans como organismo modelo.
Se ha investigado la absorción de hierro y el crecimiento del huésped en respuesta al Ent.
Interacciones examinadas con la subunidad mitocondrial de la ATP sintasa alfa.
Encontros confirmados en líneas celulares de mamíferos.

Principales resultados:

La enterobactina (Ent) apoya significativamente el crecimiento de C. elegans y la reserva de hierro lábil.
Ent promueve la absorción de hierro mitocondrial a través de la interacción con la subunidad alfa de la ATP sintasa.
Esta interacción es independiente de la función de la ATP sintasa.
El mecanismo se conserva en las células de los mamíferos.

Conclusiones:

La enterobactina (Ent) tiene un papel beneficioso en la homeostasis del hierro del huésped.
Se identifica un nuevo mecanismo para la absorción de hierro mitocondrial que involucra a la subunidad alfa de la ATP sintasa.
Este descubrimiento redefine la dinámica de intercambio de hierro entre el huésped y el microbio.

Palabras clave:

El ATP-1 ATP-2 y sus derivados ATP5A1 y sus derivados E. coli y sus derivados Lipocalina y sus derivados Enterobacterias microbios intestinales Deficiencia de hierro Piscina de hierro lábil El tiroteo por el hierro.

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