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Subsistemas de Serotonina del Raphe Dorsal anatómicamente definidos y funcionalmente distintos

Jing Ren1, Drew Friedmann1, Jing Xiong2

  • 1Department of Biology and Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.

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|August 28, 2018
PubMed
Resumen
Este resumen es generado por máquina.

El sistema de serotonina del rafe dorsal (DR) no es una unidad única. Diferentes poblaciones de neuronas DR se proyectan a distintas áreas del cerebro, influyendo en la ansiedad y los comportamientos de afrontamiento.

Palabras clave:
El 5-HTTph2Vgluto y sus derivadosAnsiedadla amígdala centralla depresiónRafe dorsoFotometría por fibraiDISCO (en inglés)corteza frontal orbitaly la serotonina

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Área de la Ciencia:

  • La neurociencia
  • Neurobiología
  • Sistemas de la serotonina

Sus antecedentes:

  • El raphe dorsal (DR) es una fuente clave de serotonina en el cerebro anterior.
  • Influye en el estado de ánimo, la ansiedad y las funciones motoras.
  • Los estudios anteriores trataron las neuronas de serotonina DR como una población uniforme.

Objetivo del estudio:

  • Para investigar la heterogeneidad funcional de las neuronas de serotonina DR.
  • Para diferenciar entre las poblaciones de neuronas de serotonina DR de proyección subcortical y cortical.

Principales métodos:

  • Se emplearon técnicas de rastreo genético viral.
  • Análisis de la coexpresión del transportador vesicular de glutamato.
  • Mapeo de colateralización de todo el cerebro.
  • Investigación de las entradas presinápticas.
  • Experimentos de ganancia y pérdida de función.

Principales resultados:

  • Las neuronas de serotonina DR de proyección subcortical y cortical muestran distribuciones y patrones de coexpresión distintos.
  • Las neuronas que proyectan la amígdala y la corteza frontal exhiben conectividad complementaria y entradas sesgadas.
  • Estas poblaciones distintas responden de manera opuesta a los estímulos aversivos.
  • Las neuronas que proyectan la amígdala promueven la ansiedad; las neuronas que proyectan la corteza frontal promueven el afrontamiento activo.

Conclusiones:

  • El sistema de serotonina DR comprende subsistemas paralelos y funcionalmente distintos.
  • Estos subsistemas difieren en conectividad, propiedades de respuesta y roles de comportamiento.
  • Este hallazgo refina nuestra comprensión del papel de la serotonina en la función y el comportamiento del cerebro.