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Redes dinámicas multiconstituyentes basadas en ADN: control adaptativo jerárquico sobre la composición y las
Zhixin Zhou1, Liang Yue1, Shan Wang1
1Institute of Chemistry , The Hebrew University of Jerusalem , Jerusalem 91904 , Israel.
Journal of the American Chemical Society
|August 31, 2018
Resumen
Los investigadores crearon redes dinámicas constitucionales adaptativas (CDN) utilizando secuencias de ácido nucleico. Los desencadenantes hacen que las CDN se reconfiguren, cambiando los niveles constituyentes y permitiendo nuevas funciones catalíticas.
Área de la Ciencia:
- Química supramolecular
- Química de los sistemas
- Biotecnología
Sus antecedentes:
- Las redes dinámicas constitucionales (CDN) ofrecen sistemas moleculares adaptativos y receptivos.
- El control de la reconfiguración de CDN es clave para diseñar arquitecturas moleculares sofisticadas.
- Los sistemas basados en ácido nucleico proporcionan una plataforma versátil para la construcción de redes moleculares dinámicas.
Objetivo del estudio:
- Construir y demostrar la reconfiguración adaptativa y jerárquica de las RCD [3 × 2] y [3 × 3].
- Investigar el papel de los desencadenantes en la estabilización y reconfiguración de los componentes de la CDN.
- Explorar las funciones catalíticas emergentes dentro de las CDN reconfiguradas.
Principales métodos:
- Construcción de CDN utilizando secuencias de bases de ácido nucleico, formando redes [3 × 2] o [3 × 3].
- Utilizando disparadores de cadena única para la hibridación y la estabilización de componentes específicos de CDN.
- Incorporación de enzimas dependientes de iones Mg2+ para el análisis cuantitativo de los niveles de los constituyentes mediante fluorescencia.
Principales resultados:
- Se ha demostrado la reconfiguración adaptativa y jerárquica de las CDN en respuesta a desencadenantes específicos.
- Se observa una regulación ascendente de los componentes no conectados y una regulación descendente de los componentes conectados en el momento de la activación.
- Se mostraron las transiciones desencadenadas en diferentes CDN y las actividades catalíticas emergentes en la CDN [3 × 3].
Conclusiones:
- Las CDN basadas en ácido nucleico se pueden reconfigurar de manera adaptativa y jerárquica utilizando disparadores externos.
- Las transiciones dinámicas dentro de las CDN permiten la aparición de nuevas funciones catalíticas.
- Este trabajo proporciona un marco para diseñar sistemas moleculares complejos y sensibles con propiedades sintonizables.
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