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In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein
Published on: January 2, 2015
Las estructuras de los filamentos de la enfermedad de Pick revelan un nuevo pliegue de proteína tau
Benjamin Falcon1, Wenjuan Zhang1, Alexey G Murzin1
1MRC Laboratory of Molecular Biology, Cambridge, UK.
Nature
|August 31, 2018
Resumen
Los investigadores descubrieron distintas estructuras de proteína tau en la enfermedad de Pick, que difieren de la enfermedad de Alzheimer. Este hallazgo explica el papel de tau en las enfermedades neurodegenerativas y cómo se propagan las estructuras proteicas.
Área de la Ciencia:
- La neurociencia
- Biología estructural
- La bioquímica
Sus antecedentes:
- El ensamblaje anormal de la proteína tau causa enfermedades neurodegenerativas.
- Los filamentos Tau muestran una propagación específica de la enfermedad y se correlacionan con los síntomas.
- Existen seis isoformas de tau: tau 3R y tau 4R.
Objetivo del estudio:
- Determinar la estructura de los filamentos tau en la enfermedad de Pick.
- Investigar si la tau puede adoptar conformaciones moleculares específicas de la enfermedad.
- Comprender la base estructural de la patología tau en diferentes trastornos neurodegenerativos.
Principales métodos:
- Se utilizó la criomicroscopia electrónica para determinar las estructuras de los filamentos.
- Análisis estructural de filamentos tau de pacientes con la enfermedad de Pick.
- Comparación con estructuras previamente determinadas de filamentos tau de pacientes con enfermedad de Alzheimer.
Principales resultados:
- Los filamentos tau en la enfermedad de Pick consisten en residuos Lys254-Phe378 de tau 3R.
- El pliegue tau determinado en la enfermedad de Pick es distinto del de la enfermedad de Alzheimer.
- Esta diferencia estructural explica la incorporación selectiva de 3R tau y la fosforilación alterada en la enfermedad de Pick.
Conclusiones:
- Tau puede adoptar pliegues distintos y específicos de la enfermedad en el cerebro humano.
- Estos hallazgos establecen la existencia de conformistas tau.
- Comprender estos conformadores es crucial para la investigación de enfermedades neurodegenerativas.
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