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Liberación de la levadura de la adicción al alcohol (sólo) para hacer grasa en su lugar
Kiran R Patil1, Markus Ralser2
1European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.
Cell
|September 8, 2018
Resumen
Los investigadores reprogramaron el metabolismo de la levadura, cambiándolo de la producción de etanol a la síntesis de grandes cantidades de ácidos grasos libres a través de la ingeniería genética y la evolución en el laboratorio.
Área de la Ciencia:
- Biología sintética
- Ingeniería metabólica
- Biología de las células eucariotas
Sus antecedentes:
- El metabolismo celular eucariota está evolucionariamente conservado y es difícil de diseñar.
- Comprender las vías metabólicas es clave para reprogramar las funciones celulares.
Objetivo del estudio:
- Investigar si el metabolismo eucariótico puede ser rediseñado sintéticamente.
- Para reprogramar el metabolismo de Saccharomyces cerevisiae para la síntesis de nuevos productos.
Principales métodos:
- La orquestación de múltiples modificaciones genéticas en Saccharomyces cerevisiae.
- Aplicación de las técnicas de evolución de laboratorio.
- Análisis del flujo metabólico para confirmar la redirección de la vía.
Principales resultados:
- Cambió con éxito el metabolismo de la levadura de la producción de etanol a la síntesis de ácidos grasos libres.
- Se obtienen altos rendimientos de ácidos grasos libres, lo que demuestra una reprogramación metabólica efectiva.
- Se han identificado objetivos genéticos clave para la redirección de la vía metabólica.
Conclusiones:
- Las vías metabólicas eucariotas no están completamente conectadas y pueden ser rediseñadas sintéticamente.
- Este estudio proporciona una plataforma novedosa para producir compuestos valiosos como ácidos grasos libres utilizando levadura de ingeniería.
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