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The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice
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La sensibilidad al tacto y al dolor neuropático táctil está determinada por las proyecciones corticospinales
Yuanyuan Liu1,2, Alban Latremoliere1,3, Xinjian Li4,5
1F. M. Kirby Neurobiology Center and Department of Neurology, Boston Children's Hospital, Boston, MA, USA.
Nature
|September 14, 2018
Resumen
El cerebro
Área de la Ciencia:
- La neurociencia
- Sistema somatosensorial
- Percepción del dolor
Sus antecedentes:
- Los modelos tradicionales se centran en las vías sensoriales ascendentes al cerebro.
- Se cree que la influencia mental de arriba hacia abajo en la percepción es cerebral.
- El tracto corticospinal (CST) es principalmente una vía motora.
Objetivo del estudio:
- Para investigar el control cortical directo de arriba hacia abajo del procesamiento sensorial espinal.
- Para explorar el papel del CST en la percepción somatosensorial.
- Para entender los mecanismos neuronales de la alodinia táctil.
Principales métodos:
- Neuronas corticospinales (CSN) examinadas originadas en la corteza somatosensorial.
- Reducción de la actividad de la RSC o seccionamiento del CST en ratones.
- Se evaluaron las respuestas conductuales a estímulos táctiles y nocivos, y alodinia táctil.
Principales resultados:
- Reducción de la actividad somatosensorial de la RSC o alteración de las respuestas al tacto con la luz.
- Estas manipulaciones no afectaron las respuestas a estímulos nocivos.
- La manipulación de la CNS atenuó la alodinia táctil y reveló un bucle de sensibilización espinal-cortical-espinal.
Conclusiones:
- Existe una modulación cortical directa del procesamiento somatosensorial espinal.
- El CST juega un papel en la sensación táctil normal y patológica.
- Los hallazgos sugieren nuevos objetivos terapéuticos para el dolor neuropático.
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