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Updated: Jul 7, 2026

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
10:06

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells

Published on: April 26, 2017

Un sitio de unión determina la especificidad de la secuencia de Tetrahymena pre-rRNA autoesplicante, trans-esplicante

M D Been, T R Cech

    Cell
    |October 24, 1986
    PubMed
    Resumen

    Investigando la secuencia de intervención (IVS) del ARN pre-ribosomal (ARNr) de Tetrahymena, este estudio revela cómo las reglas específicas de emparejamiento de bases gobiernan la actividad de la enzima ARN. La alteración de las secuencias afecta la precisión de empalme y otras funciones catalíticas, lo que demuestra cambios predecibles en la especificidad de la enzima de ARN.

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