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C. elegans AWA Neuronas olfativas Fuego Potenciales de acción mediados por calcio todo o nada
Qiang Liu1, Philip B Kidd1, May Dobosiewicz1
1Lulu and Anthony Wang Laboratory of Neural Circuits and Behavior, The Rockefeller University, New York, NY 10065, USA.
Cell
|September 18, 2018
Resumen
Las neuronas de Caenorhabditis elegans presentan inesperadamente potenciales de acción, específicamente picos de calcio, en las neuronas olfativas AWA. Este hallazgo revela un nuevo mecanismo para el procesamiento de información neuronal en los nematodos.
Área de la Ciencia:
- La neurociencia
- Biología molecular
- La genética
Sus antecedentes:
- Anteriormente se pensaba que los potenciales de acción clásicos estaban ausentes en las neuronas de Caenorhabditis elegans.
- La comprensión de la señalización neuronal en los nematodos es crucial para la neurociencia comparativa.
Objetivo del estudio:
- Investigar la presencia y las características de los potenciales de acción en las neuronas olfativas AWA de C. elegans.
- Para aclarar los canales iónicos involucrados en la generación de estas señales neuronales.
Principales métodos:
- Las grabaciones de las pinzas de corriente en las neuronas de C. elegans AWA.
- Experimentos de sustitución iónica y análisis de mutantes.
- Tratamientos farmacológicos y modelado computacional.
Principales resultados:
- Se observaron picos de potencial de membrana con características de potencial de acción en las neuronas AWA.
- Se identificaron canales de calcio EGL-19 (CaV1) que inician y canales de potasio SHK-1 que terminan los picos.
- Se demostró que los estímulos del olor inducen estos picos de AWA, correlacionados con la escalada del gradiente del olor.
Conclusiones:
- Las neuronas de C. elegans, específicamente las neuronas olfativas AWA, pueden generar potenciales de acción basados en calcio.
- Estos potenciales de acción expanden las capacidades computacionales conocidas del sistema nervioso de los nematodos.
- Los hallazgos sugieren un nuevo mecanismo para la codificación neuronal y la dinámica de la red en C. elegans.
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