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Ensamblaje jerárquico reversible de péptidos trimericos en espiral en nano- y microestructuras en bandas
Monessha Nambiar1, Li-Sheng Wang2, Vincent Rotello2
1Department of Chemistry , Purdue University , 560 Oval Drive , West Lafayette , Indiana 47907-2084 , United States.
Journal of the American Chemical Society
|September 18, 2018
Resumen
Los investigadores desarrollaron péptidos de autoensamblaje que forman nanoestructuras ordenadas. Estos biomateriales péptidos pueden ser controlados por el pH, mostrando una promesa para aplicaciones como la administración de medicamentos.
Área de la Ciencia:
- Química supramolecular
- Ciencias de los materiales
- Ingeniería de biomateriales
Sus antecedentes:
- El autoensamblaje de péptidos es una estrategia clave para crear nanoestructuras complejas.
- El control del ensamblaje y las propiedades de los materiales a base de péptidos es crucial para aplicaciones avanzadas.
Objetivo del estudio:
- Diseñar y sintetizar péptidos en espiral funcionalizados con bipiridinas para el ensamblaje jerárquico.
- Investigar las características estructurales y los mecanismos de ensamblaje de estas nano- y microestructuras basadas en péptidos.
- Explorar el potencial de estos materiales para aplicaciones biológicamente relevantes, en particular la administración de fármacos con pH controlado.
Principales métodos:
- Síntesis de péptidos en espiral radialmente funcionalizados.
- Caracterización del ensamblaje jerárquico en estructuras rectangulares con bandas.
- Análisis de dispersión de rayos X para determinar aspectos estructurales más finos y embalaje.
- Investigación del ensamblaje reversible dependiente del pH.
Principales resultados:
- Se ha demostrado el ensamblaje jerárquico de péptidos en nano- y microestructuras sintonizables.
- Se estableció una correlación entre la colocación del grupo aromático y las dimensiones de la estructura.
- Identificación de las interacciones aromáticas hexagonales de los trímeres y los intertrímeres mediante dispersión de rayos X.
- Se ha confirmado la formación fácil en condiciones fisiológicas y la modulación reversible del pH del ensamblaje.
Conclusiones:
- Los péptidos en espiral funcionalizados con bipiridinas se autoensamblan en estructuras jerárquicas con dimensiones ajustables.
- Las propiedades estructurales están influenciadas por la colocación estratégica de los grupos aromáticos.
- Estos biomateriales exhiben un comportamiento de respuesta al pH reversible, adecuado para aplicaciones biológicas controladas como la administración de medicamentos.
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