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Sensación, movimiento y aprendizaje en ausencia de corteza del barril

Y Kate Hong¹, Clay O Lacefield¹, Chris C Rodgers¹

¹Department of Neuroscience, Mortimer Zuckerman Mind Brain Behavior Institute and Kavli Institute for Brain Science, Columbia University, New York, NY, USA.

|September 19, 2018

Resumen

La corteza somatosensorial primaria no es esencial para la detección de objetos utilizando bigotes. Los ratones recuperaron rápidamente la función después de su inactivación, mostrando el cerebro

Área de la Ciencia:

La neurociencia
Sistemas sensoriales
Función de la corteza cerebral

Sus antecedentes:

Se debate el papel de la corteza cerebral en la detección sensorial.
La detección activa involucra sistemas sensoriales y motores coordinados.

Objetivo del estudio:

Investigar la necesidad de la corteza somatosensorial primaria para la detección activa de objetos.
Explorar el papel de la experiencia en la recuperación de la inactivación de la corteza sensorial.

Principales métodos:

Usó optogenética y lesiones permanentes para inactivar la corteza somatosensorial primaria en ratones.
Ratones entrenados para detectar objetos usando bigotes faciales para una recompensa de agua.
Evaluar la recuperación del comportamiento y la adquisición de tareas después de la inactivación.

Principales resultados:

Inicialmente, la inactivación afectó la detección, destacando los enlaces sensorio-motores.
Los ratones recuperaron rápidamente las capacidades de comportamiento completas, demostrando plasticidad dependiente de la experiencia.
La ablación antes del aprendizaje no impidió la adquisición de tareas.

Conclusiones:

La corteza somatosensorial primaria puede ser prescindible para la detección activa de objetos.
Otras estructuras cerebrales pueden compensar el daño de la corteza sensorial.
La experiencia y la plasticidad facilitan la recuperación rápida de la función.

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