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Un cambio de paradigma en la inmunoterapia del cáncer: de la mejora a la normalización

Miguel F Sanmamed1, Lieping Chen1

  • 1Department of Immunobiology and Yale Cancer Center, Yale University School of Medicine, New Haven, CT, USA.

Cell
|October 6, 2018
PubMed
Resumen

Las inmunoterapias contra el cáncer dirigidas a la vía B7-H1 / PD-1 ofrecen respuestas mejoradas y menos efectos secundarios al restaurar la función inmune dentro del microambiente tumoral, una estrategia denominada "normalización inmune". Este enfoque guía los diseños futuros de inmunoterapia contra el cáncer.

Palabras clave:
B7-H1 y B7-H2PD-1 y sus derivadosPD-L1 y sus derivadosel cáncerinmunoterapianormalización

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