Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Interference and Diffraction02:18

Interference and Diffraction

52.4K
Interference is a characteristic phenomenon exhibited by waves. When two electromagnetic waves interact with their peaks and troughs coinciding, a resulting wave with enhanced amplitude is produced. This is known as constructive interference. In this case, the two waves interacting are in phase with each other.
52.4K
RNA Interference01:23

RNA Interference

28.1K
RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
28.1K
Interference and Decay01:16

Interference and Decay

469
Forgetting is a complex cognitive phenomenon influenced by several factors, among which interference and decay are particularly prominent. These processes explain why individuals often struggle to retrieve specific information from memory, leading to lapses in recall that can be observed in everyday situations.
Interference occurs when competing memories hinder the retrieval of particular information. It can be classified into two types: proactive and retroactive interference. Proactive...
469
Elimination Kinetics: First-Order and Zero-Order01:05

Elimination Kinetics: First-Order and Zero-Order

2.9K
Eliminating drugs from the body is a vital process that occurs through excretion or metabolism. Understanding the kinetics of drug elimination is crucial for drug development, dosage determination, and optimizing patient outcomes.
Drug clearance depends on the rate of drug elimination and its plasma concentration. Another important parameter is a drug's half-life, which is the time required for its concentration to decrease by half. In most cases, drug clearance follows first-order...
2.9K
Elimination Reactions02:25

Elimination Reactions

17.0K
A nucleophile can react with an alkyl halide to give the substitution product by displacing the halogen. Or it can function as a base to give the elimination product by deprotonation of the neighboring carbon to form an alkene. In an elimination reaction, the substrate loses two groups from adjacent carbons forming at least one π bond. The carbon attached to the halogen is called the α carbon, while the adjacent carbon is called the β carbon; hence, these reactions are called...
17.0K
Radical Formation: Elimination00:51

Radical Formation: Elimination

2.4K
Another method of radical formation is the elimination process. It is the opposite of the addition route and is driven by the instability of the radical. For example, as depicted in Figure 1, dibenzoyl peroxide yields a pair of unstable radicals upon homolysis. Given its instability, this radical spontaneously undergoes elimination via a C–C bond cleavage to form a relatively more stable phenyl radical. The mechanism involves cleavage of the bond between the α and β positions with respect...
2.4K

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

A pilot randomized clinical trial evaluating the feasibility, acceptability, and preliminary efficacy of a cognitive-behavioral therapy adjunct to support benzodiazepine tapering among primary care patients coprescribed benzodiazepines and opioids.

Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors·2026
Same author

Ketogenic diet synergistic reprogramming of both host and microbiome promotes tissue regeneration.

bioRxiv : the preprint server for biology·2026
Same author

Human Intestinal Spirochetosis as a Cause of Chronic Diarrhea in an Immunocompetent Patient: A Case Report.

Cureus·2026
Same author

Cryo-EM analysis of the Staphylococcus aureus phenol-soluble modulin exporter PmtCD apo form in detergent micelles, nanodiscs and peptidiscs.

Communications biology·2025
Same author

Host DNA damage and cellular fate in bacterial infections, with a focus on Staphylococcus aureus.

FEMS microbiology reviews·2025
Same author

Quorum-sensing control of sepsis in the coagulase-negative staphylococcal species Staphylococcus haemolyticus.

Cell reports·2025

Video Experimental Relacionado

Updated: Feb 4, 2026

Opsono-Adherence Assay to Evaluate Functional Antibodies in Vaccine Development Against Bacillus anthracis and Other Encapsulated Pathogens
13:47

Opsono-Adherence Assay to Evaluate Functional Antibodies in Vaccine Development Against Bacillus anthracis and Other Encapsulated Pathogens

Published on: May 19, 2020

3.9K

Eliminación del patógeno por el probiótico Bacillus mediante la interferencia de la señalización

Pipat Piewngam1,2, Yue Zheng1, Thuan H Nguyen1

  • 1Pathogen Molecular Genetics Section, Laboratory of Bacteriology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

Nature
|October 12, 2018
PubMed
Resumen
Este resumen es generado por máquina.

Las bacterias probióticas Bacillus, a través de los lipopéptidos de la fengicina, eliminan al Staphylococcus aureus bloqueando su detección de quórum. Este mecanismo probiótico reduce la colonización de patógenos y ofrece nuevas estrategias para la descolonización y la lucha contra las infecciones.

Más Videos Relacionados

Investigating the Alleviating Effects of Bacillus cereus Administration on Colitis through Gut Microbiota Modulation
08:34

Investigating the Alleviating Effects of Bacillus cereus Administration on Colitis through Gut Microbiota Modulation

Published on: July 27, 2022

1.3K
Application of CRISPR Interference CRISPRi for Gene Silencing in Pathogenic Species of Leptospira
14:49

Application of CRISPR Interference CRISPRi for Gene Silencing in Pathogenic Species of Leptospira

Published on: August 14, 2021

5.7K

Videos de Experimentos Relacionados

Last Updated: Feb 4, 2026

Opsono-Adherence Assay to Evaluate Functional Antibodies in Vaccine Development Against Bacillus anthracis and Other Encapsulated Pathogens
13:47

Opsono-Adherence Assay to Evaluate Functional Antibodies in Vaccine Development Against Bacillus anthracis and Other Encapsulated Pathogens

Published on: May 19, 2020

3.9K
Investigating the Alleviating Effects of Bacillus cereus Administration on Colitis through Gut Microbiota Modulation
08:34

Investigating the Alleviating Effects of Bacillus cereus Administration on Colitis through Gut Microbiota Modulation

Published on: July 27, 2022

1.3K
Application of CRISPR Interference CRISPRi for Gene Silencing in Pathogenic Species of Leptospira
14:49

Application of CRISPR Interference CRISPRi for Gene Silencing in Pathogenic Species of Leptospira

Published on: August 14, 2021

5.7K

Área de la Ciencia:

  • Microbiología
  • Salud humana
  • Nutrición probiótica

Sus antecedentes:

  • Se afirma que los alimentos probióticos mejoran la salud humana al reducir la colonización de patógenos.
  • Los mecanismos precisos detrás de estos beneficios para la salud no se comprenden completamente.
  • La reducción de la susceptibilidad al patógeno es un área clave de investigación en enfermedades infecciosas.

Objetivo del estudio:

  • Investigar los mecanismos moleculares por los cuales las bacterias probióticas reducen la colonización de patógenos.
  • Determinar la eficacia del probiótico Bacillus en la prevención de la colonización de Staphylococcus aureus.
  • Explorar nuevas estrategias para combatir las infecciones por Staphylococcus aureus.

Principales métodos:

  • Consumo de bacterias probióticas Bacillus por una población tailandesa rural.
  • Análisis de los lipopéptidos de Bacillus, específicamente las fengicinas.
  • Investigación de las vías de detección de quórum de Staphylococcus aureus.

Principales resultados:

  • El consumo de Bacillus probiótico impidió por completo la colonización de Staphylococcus aureus.
  • Se identificaron las fengicinas como los compuestos activos responsables de la eliminación de S. aureus.
  • Las fengicinas inhiben la detección de quórum de S. aureus, un sistema de comunicación bacteriana.
  • Este mecanismo demuestra la interferencia bacteriana probiótica mediante el bloqueo de la señalización del patógeno.

Conclusiones:

  • La nutrición probiótica, específicamente el consumo de Bacillus, reduce efectivamente la colonización de Staphylococcus aureus.
  • Las fengicinas juegan un papel crucial en la eficacia probiótica al interrumpir la detección de quórum de S. aureus.
  • El bloqueo de los sistemas de señalización de patógenos ofrece una vía prometedora para la descolonización y el control de la infección.
  • Este estudio proporciona una base molecular para los beneficios de los probióticos para reducir el riesgo de enfermedades infecciosas.