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Carbotoxicidad - Efectos nocivos de los carbohidratos

Guido Kroemer¹, Carlos López-Otín², Frank Madeo³

¹Equipe 11 labellisée par la Ligue contre le Cancer, Centre de Recherche des Cordeliers, Paris, France; Cell Biology and Metabolomics Platforms, Gustave Roussy Cancer Campus, Villejuif, France; INSERM, U1138, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Université Pierre et Marie Curie, Paris, France; Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, Paris, France; Karolinska Institute, Department of Women's and Children's Health, Karolinska University Hospital, Stockholm, Sweden.

|October 20, 2018

Resumen

El consumo excesivo de carbohidratos, denominado "carbotoxicidad", tiene un impacto negativo en la salud humana y acelera el envejecimiento. La reducción del consumo de carbohidratos muestra efectos beneficiosos, y se discuten estrategias para combatir esta condición.

Área de la Ciencia:

Ciencias de la nutrición
Salud metabólica
Investigación sobre el envejecimiento

Sus antecedentes:

Las dietas modernas cuentan con un exceso de carbohidratos (de polisacáridos digestibles a azúcares refinados).
El alto consumo de carbohidratos está relacionado con resultados adversos para la salud.
Este fenómeno se llama "carbotoxicidad".

Objetivo del estudio:

Para explorar los impactos negativos en la salud de la ingesta excesiva de carbohidratos.
Discutir los mecanismos que vinculan el alto consumo de carbohidratos con la enfermedad y el envejecimiento.
Desarrollar estrategias para combatir la carbotoxicidad.

Principales métodos:

Revisión de la evidencia epidemiológica y experimental.
Análisis de los ensayos de intervención clínica.
Discusión de los mecanismos moleculares, celulares y neuroendocrinos.

Principales resultados:

La evidencia confirma los efectos perjudiciales de la ingesta excesiva de carbohidratos.
La reducción de la ingesta de carbohidratos demuestra beneficios para la salud.
Se identifican los mecanismos que vinculan la ingesta de carbohidratos con la enfermedad y el envejecimiento.

Conclusiones:

El consumo excesivo de carbohidratos (carbotoxicidad) plantea riesgos significativos para la salud.
La modificación de la dieta y las intervenciones farmacológicas pueden combatir la carbotoxicidad.
Comprender estos mecanismos es crucial para mejorar la salud metabólica y la longevidad.

Palabras clave:

envejecimiento la diabetes el régimen alimenticio la salud la longevidad el metabolismo La nutrición Obesidad restricción el azúcar

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