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Mapeo de la trayectoria de unión de un inhibidor del suicidio en la indoleamina 2,3-dioxigenasa 1 humana

Khoa N Pham1, Syun-Ru Yeh1

  • 1Department of Physiology and Biophysics , Albert Einstein College of Medicine , Bronx , New York 10461 , United States.

Journal of the American Chemical Society
|October 24, 2018
PubMed
Resumen

Este estudio revela el mecanismo de unión completo de BMS-986205, un nuevo inhibidor suicida dirigido a la indoleamina 2,3-dioxigenasa 1 humana (hIDO1) para la inmunoterapia contra el cáncer. Las ideas estructurales explican su alta eficacia y su inhibición única.

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