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Polymers02:34

Polymers

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The word polymer is derived from the Greek words “poly” which means “many” and “mer” which means “parts”. Polymers are long chains of molecules composed of repeating units of smaller molecules, known as monomers. They either occur naturally, such as DNA and proteins, or can be constructed synthetically, like plastics. They have varied structural characteristics, such as linear chains, branched chains, or complex networks, that contribute to the...
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Polymers02:34

Polymers

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DNA Replication02:40

DNA Replication

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DNA replication involves the separation of the two strands of the double helix, with each strand serving as a template from which the new complementary strand is copied.  After replication, each double-stranded DNA includes one parental or “old” strand and one “new” strand. This is known as semiconservative replication. The resulting DNA molecules have the same sequence and are divided equally into the two daughter cells.
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Dynamic Equilibrium02:20

Dynamic Equilibrium

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A reversible chemical reaction represents a chemical process that proceeds in both forward (left to right) and reverse (right to left) directions. When the rates of the forward and reverse reactions are equal, the concentrations of the reactant and product species remain constant over time and the system is at equilibrium. A special double arrow is used to emphasize the reversible nature of the reaction. The relative concentrations of reactants and products in equilibrium systems vary greatly;...
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Polymer Classification: Architecture01:14

Polymer Classification: Architecture

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Polymers are classified as linear or branched on the basis of their chain architecture. The polymer chains in linear polymers have a long chain-like structure with minimal to no branching at all. Even if a polymer features large substituent groups on the monomer, which appear as branches to the skeleton, it is not considered a branched polymer. A branched polymer contains secondary polymer chains that arise from the main polymer chain. The branching occurs when the polymer growth shifts from...
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Polymer Classification: Crystallinity01:21

Polymer Classification: Crystallinity

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Unlike ionic or small covalent molecules, polymers do not form crystalline solids due to the diffusion limitations of their long-chain structures. However, polymers contain microscopic crystalline domains separated by amorphous domains.
Crystalline domains are the regions where polymer chains are aligned in an orderly manner and held together in proximity by intermolecular forces. For example, chains in the crystalline domains of polyethylene and nylon are bound together by van der Waals...
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Polímeros similares al ADN dinámicos y sensibles

Sudheendran Mavila1, Brady T Worrell1, Heidi R Culver1

  • 1Department of Chemical and Biological Engineering , University of Colorado-Boulder , Boulder , Colorado 80309 , United States.

Journal of the American Chemical Society
|October 24, 2018
PubMed
Resumen
Este resumen es generado por máquina.

Los investigadores sintetizaron nuevos monómeros de tiolactona para la polimerización de apertura de anillos (ROP). Estos polímeros permiten el reordenamiento dinámico a través del intercambio tiol-tioester, lo que permite la síntesis de polímeros controlados.

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Área de la Ciencia:

  • Química de los polímeros
  • Síntesis orgánica
  • Ciencias de los materiales

Sus antecedentes:

  • Los análogos de nucleósidos son cruciales en varias aplicaciones.
  • La polimerización por apertura de anillos (ROP) es una técnica de polimerización versátil.
  • La síntesis controlada de polímeros sigue siendo un desafío importante.

Objetivo del estudio:

  • Desarrollar nuevos monómeros de tiolactona que imiten los nucleósidos naturales.
  • Para investigar la polimerización de apertura de anillos (ROP) de estos monómeros.
  • Explorar las capacidades de reordenamiento dinámico de los polímeros resultantes para la síntesis controlada.

Principales métodos:

  • Síntesis de monómeros de tiolactona diseñados para imitar los nucleósidos.
  • Ejecución de polimerizaciones robustas de apertura de anillos (ROP) utilizando estos monómeros.
  • Demostración de la reorganización dinámica del polímero mediante el intercambio tiol-tioester, incluida la despolimerización y la coalescencia del polímero.

Principales resultados:

  • Síntesis exitosa de monómeros de tiolactona.
  • La polimerización robusta de apertura de anillos (ROP) produce polímeros con grupos funcionales tioéster.
  • Se ha demostrado la viabilidad de la reorganización dinámica de polímeros, incluida la despolimerización y la fusión de polímeros con diferentes características.

Conclusiones:

  • Los monómeros de tiolactona desarrollados y el proceso ROP permiten la creación de polímeros dinámicos.
  • El intercambio tiol-tioester proporciona un mecanismo para el reordenamiento del polímero y la síntesis controlada.
  • Este trabajo sienta las bases para una plataforma que permita la síntesis de rutina de polímeros controlados por secuencia.