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Polímeros similares al ADN dinámicos y sensibles

Sudheendran Mavila¹, Brady T Worrell¹, Heidi R Culver¹

¹Department of Chemical and Biological Engineering , University of Colorado-Boulder , Boulder , Colorado 80309 , United States.

Journal of the American Chemical Society

|October 24, 2018

Resumen

Los investigadores sintetizaron nuevos monómeros de tiolactona para la polimerización de apertura de anillos (ROP). Estos polímeros permiten el reordenamiento dinámico a través del intercambio tiol-tioester, lo que permite la síntesis de polímeros controlados.

Área de la Ciencia:

Química de los polímeros
Síntesis orgánica
Ciencias de los materiales

Sus antecedentes:

Los análogos de nucleósidos son cruciales en varias aplicaciones.
La polimerización por apertura de anillos (ROP) es una técnica de polimerización versátil.
La síntesis controlada de polímeros sigue siendo un desafío importante.

Objetivo del estudio:

Desarrollar nuevos monómeros de tiolactona que imiten los nucleósidos naturales.
Para investigar la polimerización de apertura de anillos (ROP) de estos monómeros.
Explorar las capacidades de reordenamiento dinámico de los polímeros resultantes para la síntesis controlada.

Principales métodos:

Síntesis de monómeros de tiolactona diseñados para imitar los nucleósidos.
Ejecución de polimerizaciones robustas de apertura de anillos (ROP) utilizando estos monómeros.
Demostración de la reorganización dinámica del polímero mediante el intercambio tiol-tioester, incluida la despolimerización y la coalescencia del polímero.

Principales resultados:

Síntesis exitosa de monómeros de tiolactona.
La polimerización robusta de apertura de anillos (ROP) produce polímeros con grupos funcionales tioéster.
Se ha demostrado la viabilidad de la reorganización dinámica de polímeros, incluida la despolimerización y la fusión de polímeros con diferentes características.

Conclusiones:

Los monómeros de tiolactona desarrollados y el proceso ROP permiten la creación de polímeros dinámicos.
El intercambio tiol-tioester proporciona un mecanismo para el reordenamiento del polímero y la síntesis controlada.
Este trabajo sienta las bases para una plataforma que permita la síntesis de rutina de polímeros controlados por secuencia.

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