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El tálamo paraventricular es un área crítica para la vigilia
Shuancheng Ren1, Yaling Wang1, Faguo Yue1,2
1Department of Physiology, Collaborative Innovation Center for Brain Science, Third Military Medical University, Chongqing 400038, China.
Science (New York, N.Y.)
|October 27, 2018
Resumen
Los investigadores identificaron el tálamo paraventricular (PVT) como una región clave del cerebro que controla la vigilia. La activación de estas neuronas específicas promueve la vigilia y acelera la recuperación de la anestesia.
Área de la Ciencia:
- La neurociencia
- Investigación del sueño
- Función del tálamo
Sus antecedentes:
- Se sabe que el tálamo paramediano influye en la vigilia.
- El núcleo específico y las vías neuronales responsables de este control no se comprenden bien.
Objetivo del estudio:
- Identificar el núcleo tálamico específico y sus circuitos neuronales involucrados en la regulación de la vigilia.
- Investigar el papel del tálamo paraventricular (PVT) en el control de la vigilia.
Principales métodos:
- Fotometría de fibras in vivo y grabaciones electrofisiológicas multicanal en ratones.
- Manipulación de la actividad de las neuronas glutamatérgicas del tálamo paraventricular (PVT).
Principales resultados:
- Las neuronas glutamatérgicas en el PVT mostraron una alta actividad durante la vigilia.
- La supresión de la actividad neuronal PVT disminuyó la vigilia.
- La activación de las neuronas PVT promovió la vigilia y aceleró la salida de la anestesia.
Conclusiones:
- El tálamo paraventricular (PVT) es un núcleo crítico para controlar la vigilia.
- Las proyecciones PVT al núcleo accumbens y las entradas de las neuronas hipocretinas hipotalámicas laterales son vías efectoras clave para la regulación de la vigilia.
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