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Transporte de ATP impulsado por la luz controlado por nanomáquinas de ADN

Pei Li^1,2, Ganhua Xie¹, Pei Liu^1,3

¹CAS Key Laboratory of Bio-Inspired Materials and Interfacial Science , Technical Institute of Physics and Chemistry, Chinese Academy of Sciences , Beijing 100190 , People's Republic of China.

Journal of the American Chemical Society

|October 30, 2018

Resumen

Los científicos crearon nanomáquinas de ADN controladas por luz para el transporte selectivo de ATP a través de las membranas. Este sistema biomimético ofrece nuevas posibilidades para la separación molecular y el transporte transmembrana.

Área de la Ciencia:

Ingeniería biomimética
Nanotecnología
El transporte molecular

Sus antecedentes:

Las máquinas biológicas mantienen el metabolismo del organismo.
Los motores moleculares artificiales están inspirados en la naturaleza.
El transporte selectivo de biomoléculas a través de membranas es un desafío.

Objetivo del estudio:

Para establecer un sistema de transporte de ATP utilizando nanomáquinas de ADN controladas por la luz.
Para demostrar el transporte selectivo de carga a través de nanocanales artificiales.

Principales métodos:

El ensamblaje de las nanomáquinas de ADN fotocontroladas en nanocanales artificiales.
Utilizando la irradiación de luz alterna para controlar el transporte.
El transporte de moléculas de trifosfato de adenosina (ATP).

Principales resultados:

Se ha establecido con éxito un sistema de transporte de ATP.
Se ha demostrado el transporte selectivo de carga a través de una membrana de polímero utilizando nanomáquinas de ADN controladas por luz.
Demostró la capacidad de pastorear cargas con radiación de luz alterna.

Conclusiones:

Las nanomáquinas de ADN fotocontroladas pueden lograr el transporte selectivo a través de la membrana.
Esta tecnología ofrece nuevos métodos para el transporte masivo y la separación.
Las aplicaciones potenciales incluyen el transporte de otras moléculas e iones a través de la luz.

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