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Trifluorometoxilación catalizada por cobalto de los epóxidos
Jie Liu1, Yongliang Wei1, Pingping Tang1,2
1State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry , Nankai University , Tianjin 300071 , China.
Journal of the American Chemical Society
|October 30, 2018
Resumen
Una nueva reacción catalizada por cobalto permite la síntesis directa de trifluorometoxihidrinas vecinas a partir de epoxidos. Este método eficiente ofrece una ruta sencilla a valiosos compuestos trifluorometoxilados bajo condiciones suaves.
Área de la Ciencia:
- Química orgánica
- Catálisis
- Química del fluor
Sus antecedentes:
- Los epóxidos son productos intermedios sintéticos versátiles.
- La trifluorometoxilación es una transformación clave en la química medicinal.
- Los métodos directos para sintetizar compuestos trifluorometoxilados son muy buscados.
Objetivo del estudio:
- Desarrollar un nuevo método catalítico para la reacción de apertura de anillos de epóxidos.
- Para lograr la trifluorometoxilación nucleofílica de los epoxidos mediante el uso de trifluorometil arilsulfonato.
- Para sintetizar trifluorometoxihidrinas de manera eficiente y selectiva.
Principales métodos:
- Apertura de anillos catalizados por cobalto de los epoxidos.
- Se recomienda la utilización de un método de extracción de agua para el tratamiento de las aguas residuales de las aguas residuales.
- Se emplearon condiciones de reacción leves.
Principales resultados:
- Se estableció una vía directa y eficiente para la síntesis de trifluorometoxihidrinas vicinales.
- La reacción demostró una buena quimioselectividad y regioselectividad, particularmente con los epóxidos terminales.
- Una amplia gama de epóxidos se convirtió con éxito en los productos objetivo.
Conclusiones:
- La reacción catalizada por cobalto desarrollada proporciona un método fácil para la construcción de trifluorometoxihidrinas.
- Este enfoque ofrece una herramienta valiosa para introducir el grupo trifluorometoxi en moléculas orgánicas.
- La eficiencia y la selectividad del método lo hacen atractivo para aplicaciones sintéticas.
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