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Definición del degroma del dedo de zinc C2H2 humano al que se dirigen los análogos de la talidomida a través del CRBN

Quinlan L Sievers1,2, Georg Petzold3, Richard D Bunker3

  • 1Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.

Science (New York, N.Y.)
|November 3, 2018
PubMed
Resumen

Los análogos de talidomida se dirigen a las proteínas del dedo de zinc Cys2-His2 para su degradación por la CRL4CRBN E3 ubiquitina ligasa. Este estudio identifica nuevas degronas de dedo de zinc, expandiendo objetivos terapéuticos previamente considerados no farmacológicos.

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