Video Experimental Relacionado
Updated: Feb 2, 2026
08:12
High-throughput Screening for Protein-based Inheritance in S. cerevisiae
Published on: August 8, 2017
6.7K
La herencia no mendeliana en los mamíferos está muy restringida
1Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.
Cell
|November 17, 2018
Resumen
Kazachenka, Bertozzi y sus colegas descubrieron la variabilidad epigenética en los genomas de ratones entre compañeros de camada. Este fenómeno genético influye en la transmisión de rasgos a través de generaciones, respondiendo preguntas clave sobre su prevalencia e impacto.
Área de la Ciencia:
- La genómica
- La epigenética
- Biología del desarrollo
Sus antecedentes:
- Se ha observado variabilidad epigenética entre individuos genéticamente idénticos (compañeros de camada), pero poco comprendida.
- La prevalencia y los efectos transgeneracionales de tales diferencias epigenéticas se mantuvieron en gran medida especulativos.
Objetivo del estudio:
- Identificar elementos genómicos específicos que exhiban variabilidad epigenética entre compañeros de camada de ratón.
- Investigar la prevalencia y las consecuencias fenotípicas de estos elementos epigenéticos variables dentro y entre generaciones.
Principales métodos:
- Análisis comparativo de las marcas epigenéticas en los genomas de ratones.
- Evaluación de la transmisión del fenotipo en relación con las variaciones epigenéticas identificadas.
Principales resultados:
- Identificación de regiones genómicas específicas con variabilidad epigenética significativa entre compañeros de camada.
- Demostrar un vínculo entre la variabilidad epigenética y la transmisión de ciertos fenotipos a través de generaciones.
Conclusiones:
- La variabilidad epigenética entre compañeros de camada es un fenómeno cuantificable con implicaciones para la herencia.
- Estos hallazgos proporcionan una base para comprender cómo las diferencias epigenéticas contribuyen a la diversidad fenotípica y los patrones de herencia.
Más Videos Relacionados
07:40A Noninvasive Hair Sampling Technique to Obtain High Quality DNA from Elusive Small Mammals
Published on: March 13, 2011
21.4K
08:45Mapping Cortical Dynamics Using Simultaneous MEG/EEG and Anatomically-constrained Minimum-norm Estimates: an Auditory Attention Example
Published on: October 24, 2012
15.2K
Videos de Conceptos Relacionados
02:30Genomic Imprinting and Inheritance
37.2K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
37.2K
03:17Inheritance of Chromatin Structures
7.5K
Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
7.5K
01:39Chromosomal Theory of Inheritance
60.2K
In 1866, Gregor Mendel published the results of his pea plant breeding experiments, providing evidence for predictable patterns in the inheritance of physical characteristics. The significance of his findings was not immediately recognized. In fact, the existence of genes was unknown at the time. Mendel referred to hereditary units as “factors.”
60.2K
01:29Non-nuclear Inheritance
23.2K
Most DNA resides in the nucleus of a cell. However, some organelles in the cell cytoplasm—such as chloroplasts and mitochondria—also have their own DNA. These organelles replicate their DNA independently of the nuclear DNA of the cell in which they reside. Non-nuclear inheritance describes the inheritance of genes from structures other than the nucleus.
23.2K
01:25Inheritance
1.6K
Gregor Mendel's pioneering work on the principles of inheritance fundamentally transformed our understanding of how traits are transmitted from generation to generation. His experiments with pea plants laid the groundwork for the discovery of genes, discrete units within organisms that control heredity.
Each gene exists in pairs, and the combination of these genes from both parents forms an individual's genotype. This genotype is a blueprint of potential traits. Examples of genotype...
Each gene exists in pairs, and the combination of these genes from both parents forms an individual's genotype. This genotype is a blueprint of potential traits. Examples of genotype...
1.6K
02:32Position-effect Variegation
7.1K
In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and spread out in the interphase nucleus, others do not. He termed them euchromatin and heterochromatin, respectively. He proposed that the heterochromatin regions reflect a functionally inactive state of the genome. It was later confirmed that heterochromatin is transcriptionally repressed, and euchromatin is transcriptionally active chromatin.
7.1K