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Estructuras y mecanismo de retención del TRPM2 humano

Longfei Wang1,2, Tian-Min Fu3,2, Yiming Zhou4,5

  • 1Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.

Science (New York, N.Y.)
|November 24, 2018
PubMed
Resumen

El estudio revela cómo el calcio (Ca2+) y la adenosina difosfato (ADP) -ribosa (ADPR) activan el canal TRPM2. Los conocimientos estructurales muestran que la unión de Ca2+ y ADPR causa cambios conformacionales, abriendo el poro del canal.

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