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Secretina: una vieja hormona con un secreto ardiente
Randall L Mynatt1, Eric Ravussin1
1Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA.
Cell
|December 1, 2018
Resumen
La secretina, una hormona intestinal, estimula la termogénesis en el tejido adiposo marrón después de las comidas. Este hallazgo revela un nuevo mecanismo de la secretina en la regulación de la saciedad y el gasto energético.
Área de la Ciencia:
- Endocrinología
- El metabolismo
- La neurociencia
Sus antecedentes:
- La termogénesis inducida por las comidas se explica típicamente por un eje intestino-cerebro-tejido adiposo marrón (BAT).
- Este eje media la termogénesis a través del sistema nervioso simpático.
Objetivo del estudio:
- Investigar el papel de la secretina en la termogénesis inducida por las comidas.
- Identificar nuevos mecanismos que regulen la saciedad y el gasto energético.
Principales métodos:
- Investigó la unión de la secretina a los receptores en el tejido adiposo marrón.
- Se evaluó el impacto de la secretina en la termogénesis y la ingesta de alimentos.
Principales resultados:
- La secretina, liberada por el intestino después de la comida, se une a los receptores en la MTD.
- La secretina estimula directamente la termogénesis en las MTD.
- La administración de Secretin inhibió la ingesta de alimentos.
Conclusiones:
- La secretina juega un papel directo en la estimulación de la termogénesis a través del tejido adiposo marrón.
- La secretina actúa como un nuevo regulador de la saciedad, influyendo en la ingesta de alimentos.
- Este descubrimiento ofrece una nueva perspectiva sobre el eje intestino-cerebro-ATB en la regulación metabólica.
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