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Desarrollo de thioisothioureas sustituidas por S como precursores eficientes de hidropersulfuro
Vinayak S Khodade1, John P Toscano1
1Department of Chemistry , Johns Hopkins University , Baltimore , Maryland 21218 , United States.
Journal of the American Chemical Society
|December 4, 2018
Resumen
Los investigadores desarrollaron nuevas tiosiotioureas sustituidas por S como precursores de los hidropersulfuros (RSSH). Estos compuestos liberan RSSH de manera eficiente y controlada en condiciones fisiológicas, abordando un desafío clave en el campo.
Área de la Ciencia:
- La bioquímica
- Química orgánica
- Biología Química
Sus antecedentes:
- Los hidropersulfuros (RSSH) son moléculas de señalización cruciales con una inestabilidad inherente.
- La generación in situ de RSSH requiere precursores efectivos, pero existen pocas opciones fisiológicamente compatibles.
- El desarrollo de precursores estables y controlables de RSSH es vital para las aplicaciones biológicas y terapéuticas.
Objetivo del estudio:
- Diseñar y sintetizar nuevas tiosiotioureas sustituidas por S como precursores de los hidropersulfuros (RSSH).
- Evaluar la eficacia y la controlabilidad de estos nuevos precursores en la liberación de RSSH en condiciones fisiológicas.
Principales métodos:
- Diseño y síntesis de nuevas tiosiotioureas sustituidas por S.
- Evaluación de la solubilidad en agua y la estabilidad de los precursores sintetizados.
- Evaluación de la cinética de liberación de RSSH en condiciones fisiológicas (pH, temperatura).
Principales resultados:
- Diseñó y sintetizó con éxito una serie de nuevas tiosiotioureas sustituidas por S.
- Se ha demostrado que estos precursores son solubles en agua y estables.
- Se ha confirmado la liberación eficiente y controlable de hidropersulfuros (RSSH) en condiciones fisiológicas.
Conclusiones:
- Las nuevas tiosiotioureas sustituidas por S representan una clase prometedora de precursores para la generación de hidropersulfuro (RSSH).
- Estos precursores ofrecen una solución viable para la administración controlada de RSSH en sistemas biológicos.
- Los compuestos desarrollados avanzan en el conjunto de herramientas para estudiar y utilizar RSSH en contextos fisiológicos.
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