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Efecto del daño oxidativo en el transporte de carga y espín en el ADN
Suryakant Mishra1, Vishvendra S Poonia1, Claudio Fontanesi2
1Department of Chemical and Biological Physics , Weizmann Institute of Science , Rehovot 76100 , Israel.
Journal of the American Chemical Society
|December 14, 2018
Resumen
El transporte dependiente del espín a través del ADN se midió utilizando un dispositivo Hall. El ADN dañado oxidativamente mostró un mayor transporte de espín, posiblemente debido a barreras de conducción alteradas o vías de transporte de carga dual.
Área de la Ciencia:
- La electrónica molecular
- La biofísica
- Nanotecnología
Sus antecedentes:
- Comprender el transporte de electrones en el ADN es crucial para la electrónica molecular.
- La polarización de espín en el transporte de carga ofrece nuevas vías para los dispositivos espintrónicos.
- Las monocapas de ADN autoensambladas en superficies proporcionan una plataforma para estudiar la conductividad molecular.
Objetivo del estudio:
- Para medir la polarización de espín y el transporte de carga en las moléculas de ADN utilizando un dispositivo Hall.
- Investigar el efecto del daño oxidativo en el transporte de carga dependiente del espín en el ADN.
- Para aclarar los mecanismos subyacentes al transporte de carga selectivo de espín en el ADN.
Principales métodos:
- Utilizó un dispositivo Hall para medir la polarización de espín de los electrones.
- Fabricado monocapas autoensambladas de ADN en la superficie del dispositivo.
- Transporte de carga analizado a través de ADN de doble cadena de diferentes longitudes y con daño oxidativo.
Principales resultados:
- Polarización de carga dependiente del espín y el transporte observado a través del ADN.
- Se ha demostrado un mejor transporte dependiente del espín a través del ADN dañado oxidativamente.
- Se propusieron dos mecanismos potenciales para el fenómeno observado: barreras de conducción alteradas o vías de transporte de carga dual.
Conclusiones:
- El transporte de carga por espín selectivo ocurre en las moléculas de ADN.
- El daño oxidativo influye significativamente en las propiedades de transporte de espín en el ADN.
- El transporte de carga en el ADN puede implicar vías paralelas con diferentes selectividades de espín, incluida una a través de la columna vertebral de ribofosfato.
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