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Divergence and Curl01:15

Divergence and Curl

3.2K
The divergence of a vector field at a point is the net outward flow of the flux out of a small volume through a closed surface enclosing the volume, as the volume tends to zero. More practically, divergence measures how much a vector field spreads out or diverges from a given point. For an outgoing flux, conventionally, the divergence is positive. The diverging point is often called the "source" of the field. Meanwhile, the negative divergence of a vector field at a point means that the vector...
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Divergence and Stokes' Theorems01:06

Divergence and Stokes' Theorems

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The divergence and Stokes' theorems are a variation of Green's theorem in a higher dimension. They are also a generalization of the fundamental theorem of calculus. The divergence theorem and Stokes' theorem are in a way similar to each other; The divergence theorem relates to the dot product of a vector, while Stokes' theorem relates to the curl of a vector. Many applications in physics and engineering make use of the divergence and Stokes' theorems, enabling us to write...
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Gene Duplication and Divergence02:37

Gene Duplication and Divergence

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The seminal work of Ohno in 1970 popularized the idea of gene duplication and divergence. DNA sequence comparison studies reveal that a large portion of the genes in bacteria, archaebacteria, and eukaryotes was  generated by gene duplication and divergence, indicating its critical role in evolution.
The duplicated copies of the gene are called Paralogs. Paralogs with similar sequences and functions form a gene family. Across several species, a large number of gene families are...
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Divergence and Curl of Electric Field01:25

Divergence and Curl of Electric Field

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The divergence of a vector is a measure of how much the vector spreads out (diverges) from a point. For example, an electric field vector diverges from the positive charge and converges at the negative charge. The divergence of an electric field is derived using Gauss's law and is equal to the charge density divided by the permittivity of space. Mathematically, it is expressed as
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Divergence and Curl of Magnetic Field01:26

Divergence and Curl of Magnetic Field

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The magnetic field due to a volume current distribution given by the Biot–Savart Law can be expressed as follows:
4.0K
Sustainable Development01:43

Sustainable Development

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As the human population continues to grow and use resources, we must be mindful of our planet’s natural limits. Sustainable development provides a pathway to maintain and improve human life now while also ensuring that future generations will have the resources that they need. The long-term success of sustainability efforts rests on understanding the interplay between human actions and ecological systems.
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Video Experimental Relacionado

Updated: Feb 1, 2026

Derivation of a Human Brain Organoid with Microglia Development
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Divergencia transcriptómica espacio-temporal entre el desarrollo del cerebro humano y el macaco

Ying Zhu1,2, André M M Sousa1, Tianliuyun Gao1

  • 1Department of Neuroscience and Kavli Institute for Neuroscience, Yale School of Medicine, New Haven, CT, USA.

Science (New York, N.Y.)
|December 15, 2018
PubMed
Resumen
Este resumen es generado por máquina.

Este estudio mapea el desarrollo cerebral en todas las especies utilizando transcriptómica, revelando patrones conservados y vínculos genéticos con trastornos del desarrollo neurológico. Estos hallazgos iluminan la evolución del cerebro humano y los orígenes de las enfermedades.

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Área de la Ciencia:

  • La neurociencia
  • La genómica
  • Biología del desarrollo

Sus antecedentes:

  • El desarrollo del sistema nervioso humano es complejo y requiere una regulación genética precisa en el tiempo y el espacio.
  • Comprender los patrones de desarrollo conservados en todas las especies es crucial para comprender la evolución y los trastornos del cerebro humano.

Objetivo del estudio:

  • Investigar los patrones transcriptómicos durante el desarrollo del cerebro de los primates (prenatal y postnatal).
  • Identificar programas de expresión génica conservados y divergentes entre especies y etapas de desarrollo.
  • Explorar las bases genéticas de la evolución del cerebro humano y los trastornos neuropsiquiátricos.

Principales métodos:

  • Generó datos transcriptómicos a nivel de tejido y de una sola célula de 16 regiones cerebrales de macaco rhesus.
  • Datos integrados de macacos con datos complementarios de desarrollo humano.
  • Analizó patrones de expresión génica espaciotemporal e identificó genes divergentes.

Principales resultados:

  • Se identificaron patrones "en forma de copa" en las diferencias transcriptómicas durante el desarrollo y entre especies, con una convergencia perinatal.
  • Gradientes topográficos transitorios observados en el neocórtex prenatal y jerarquía funcional en el desarrollo del cerebro postnatal.
  • Encontraron genes con expresión alterada vinculados al desarrollo de la corteza prefrontal prenatal, trastorno del espectro autista y esquizofrenia.

Conclusiones:

  • Los programas transcriptómicos revelan patrones conservados en el desarrollo del cerebro de los primates, ofreciendo información sobre la evolución del cerebro humano.
  • Los cambios específicos en la expresión génica están asociados con el desarrollo de regiones cerebrales distintas y la patogénesis de trastornos neuropsiquiátricos.