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Long-term Depression

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.

Long-term Depression

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
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Modulador de GABA para la depresión posparto

¹Departments of Neurology and Physiology, The David Geffen School of Medicine at UCLA, 635 Charles Young Dr. E., Los Angeles, CA 90095, USA.

|January 12, 2019

Resumen

La depresión posparto puede deberse a la recuperación tardía de los receptores GABAA del cerebro después del embarazo. Una nueva terapia implica el uso de un neurosteroide sintético para tratar este trastorno del estado de ánimo común en las nuevas madres.

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Área de la Ciencia:

La neurociencia
La psiquiatría
Endocrinología

Sus antecedentes:

El embarazo está asociado con un número reducido de receptores inhibidores de GABAA en el cerebro.
Es posible que estos niveles de receptores no se recuperen lo suficiente durante el período posparto.
Este cambio neurobiológico es una causa potencial de depresión posparto, que afecta aproximadamente al 12% de las mujeres.

Objetivo del estudio:

Investigar el vínculo entre los cambios en los receptores GABAA y la depresión posparto.
Introducir un nuevo enfoque terapéutico para la depresión posparto.

Principales métodos:

El estudio se centra en los fundamentos neurobiológicos de los trastornos del estado de ánimo posparto.
Se propone una estrategia de tratamiento que implica la administración de un neurosteroide sintético.

Principales resultados:

La recuperación retrasada de los receptores GABAA está implicada como una causa primaria de la depresión posparto.
La administración de un neurosteroide sintético es prometedora como una intervención terapéutica.

Conclusiones:

La terapia con neurosteroides ofrece un nuevo tratamiento potencial para la depresión posparto.
El tratamiento de los déficits de los receptores GABAA puede aliviar los trastornos del estado de ánimo en el período posparto.