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Se prefiere un motivo Hendecad para la formación de bobinas enrolladas heteroquirales
Dale F Kreitler1, Zhihui Yao2, Jay D Steinkruger3
1Department of Chemistry , University of Wisconsin-Madison , Madison , Wisconsin 53706 , United States.
Journal of the American Chemical Society
|January 16, 2019
Resumen
Las bobinas enroscadas heteroquirales, formadas por polipéptidos l y d, muestran una preferencia por una repetición de hendecad de 11 residuos. Este hallazgo avanza en la comprensión de las interacciones polipéptidas y el diseño de la bobina enrollada.
Área de la Ciencia:
- Biología estructural
- La bioquímica
- Ciencias de las proteínas
Sus antecedentes:
- Los conjuntos de bobina en espiral son comunes en las estructuras de proteínas.
- Las interacciones entre los péptidos l y d son poco conocidas.
- En trabajos anteriores se identificaron dímeros heteroquirales en espiral del péptido M2-TM.
Objetivo del estudio:
- Investigar las preferencias de repetición de secuencias en bobinas heteroquirales.
- Determinar si el motivo de hendecad es intrínseco al emparejamiento de hélices de manos opuestas.
- Explorar los efectos de las modificaciones de la cadena lateral en el embalaje en espiral.
Principales métodos:
- Cristalización de tres variantes del péptido M2-TM.
- Cristalografía de rayos X de alta resolución.
- Análisis de la frecuencia helicoidal y el radio de la bobina.
Principales resultados:
- Se observaron asociaciones entre bobinas heteroquirales en las tres variantes.
- Se confirmó una preferencia por un motivo de secuencia de 11 residuos (hendecad).
- Demostró que las cadenas laterales más pequeñas mejoran el embalaje en espiral.
Conclusiones:
- El motivo de hendecad es intrínseco a la formación de la bobina en espiral heteroquiral.
- La ingeniería de la cadena lateral puede optimizar el embalaje en espiral.
- Proporciona la base para el diseño de nuevas estructuras heteroquirales en espiral.
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