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Programas moleculares distintos regulan la especificidad de las sinapsis en los circuitos inhibidores corticales
Emilia Favuzzi1,2,3, Rubén Deogracias1,2,3, André Marques-Smith1,2
1Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE1 1UL, UK.
Science (New York, N.Y.)
|January 26, 2019
Resumen
Los programas moleculares específicos guían cómo se conectan las interneuronas GABAérgicas en el cerebro del ratón. Estos programas específicos de la célula dictan la orientación sináptica, dando forma a la formación de circuitos inhibidores y la función cerebral.
Área de la Ciencia:
- La neurociencia
- Biología molecular
- Biología del desarrollo
Sus antecedentes:
- Las conexiones neuronales forman redes cerebrales funcionales cruciales para las funciones cognitivas.
- Las interneuronas GABAérgicas en la corteza cerebral de los mamíferos muestran diversos patrones de conectividad esenciales para la dinámica temporal y el procesamiento de la información.
- Los mecanismos moleculares que impulsan la conectividad específica de las interneuronas siguen siendo en gran medida desconocidos.
Objetivo del estudio:
- Investigar la dinámica de transcripción de diferentes clases de interneuronas durante el desarrollo del circuito inhibidor cortical en ratones.
- Para aclarar la base molecular de la orientación sináptica específica de las interneuronas.
Principales métodos:
- Análisis de la dinámica de la transcripción en distintos subtipos de interneuronas.
- Investigación de patrones de expresión de moléculas sinápticas durante el desarrollo posnatal temprano.
Principales resultados:
- La formación de sinapsis interneuronales en las células piramidales (dendritas, soma o segmento inicial del axón) está determinada por la expresión específica del subtipo de moléculas sinápticas.
- Programas moleculares distintos están activos en diferentes clases de interneuronas durante la formación del circuito.
Conclusiones:
- Los programas moleculares específicos de la célula establecidos durante el desarrollo temprano subyacen a los patrones precisos de conectividad de las interneuronas corticales.
- Comprender estos programas es clave para descifrar el montaje y la función del circuito inhibidor.
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