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Updated: Apr 30, 2026
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Protocol for Dengue Infections in Mosquitoes A. aegypti and Infection Phenotype Determination
Published on: July 4, 2007
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El dengue
Annelies Wilder-Smith1, Eng-Eong Ooi2, Olaf Horstick3
1London School of Hygiene & Tropical Medicine, London, UK; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore; Heidelberg Institute of Global Health, University of Heidelberg, Heidelberg, Germany.
Lancet (London, England)
|January 31, 2019
Resumen
A pesar de la baja mortalidad, el dengue grave representa una carga significativa para la salud. La investigación está avanzando en diagnósticos, terapias y vacunas, pero siguen existiendo desafíos para predecir enfermedades graves y comprender la eficacia de las vacunas.
Área de la Ciencia:
- Entomología médica
- Enfermedades infecciosas
- Vacunas y vacunas
Sus antecedentes:
- El dengue grave causa importantes cargas económicas y de servicios de salud en las zonas endémicas.
- El desarrollo terapéutico para el dengue se ha retrasado a pesar de los avances en la comprensión de la patogénesis.
- La mejora dependiente de anticuerpos es un modelo clave de patogénesis del dengue, validado recientemente in vivo.
Objetivo del estudio:
- Revisar el panorama actual del manejo, diagnóstico y prevención del dengue.
- Para resaltar la investigación en curso en terapias, diagnósticos y vacunas.
- Hacer hincapié en la necesidad de mejorar las estrategias de predicción e intervención del dengue grave.
Principales métodos:
- Revisión de las estrategias actuales de gestión del dengue, incluidos los cuidados de apoyo y la hidratación.
- Discusión de tecnologías de diagnóstico emergentes, como las pruebas de amplificación de ácido nucleico en el punto de atención.
- Examen del desarrollo de la vacuna, incluida la función del estado serológico y los correlatos de protección.
Principales resultados:
- El manejo actual se basa en la observación y la hidratación para la fuga vascular.
- Las nuevas herramientas de diagnóstico tienen como objetivo mejorar la precisión y las capacidades de multiplexación.
- La investigación de biomarcadores busca predecir el dengue grave; la eficacia de la vacuna es dependiente del estado serológico.
Conclusiones:
- Existe una necesidad urgente de terapias efectivas contra el dengue y de biomarcadores fiables para la predicción de enfermedades graves.
- Comprender los correlatos entre la protección de la vacuna y el aumento de la enfermedad es fundamental.
- La integración del control de vectores con las estrategias de vacunación requiere más investigación y evaluación.
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