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During replication, the complementary strands in double-stranded DNA are synthesized at different rates. Replication first begins on the leading strand. Replication starts later, occurs more slowly, and proceeds discontinuously on the lagging strand.
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For successful DNA replication, the unwinding of double-stranded DNA must be accompanied by stabilization and protection of the separated single strands of the DNA. This crucial task is performed by single-strand DNA-binding (SSB) proteins. They bind to the DNA in a sequence-independent manner, which means that the nitrogenous bases of the DNA need not be present in a specific order for binding of SSB proteins to it. The binding of SSB proteins straightens single-stranded DNA (ssDNA) and makes...
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The double-stranded structure of DNA has two major advantages. First, it serves as a safe repository of genetic information where one strand serves as the back-up in case the other strand is damaged. Second, the double-helical structure can be wrapped around proteins called histones to form nucleosomes, which can then be tightly wound to form chromosomes. This way, DNA chains up to 2 inches long can be contained within microscopic structures in a cell. A double-stranded break not only damages...
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Intercambio de hebras inspirado en el ADN para morfologías supramoleculares basadas en PMMA intercambiables

Jing M Ren1, Abigail S Knight, Bas G P van Ravensteijn

  • 1Department of Chemical Engineering , The University of Melbourne , Parkville , Victoria 3010 , Australia.

Journal of the American Chemical Society
|February 6, 2019
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Los investigadores lograron el intercambio de hebras helicoidales sintéticas en complejos estereoscópicos de triple hélice de poli (methacrilato de metilo) (PMMA). Este avance permite la conmutación reversible de las morfologías micélicas de polímeros, allanando el camino para los nanosistemas inteligentes dinámicos.

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Área de la Ciencia:

  • Ciencias de los Polímeros
  • Química supramolecular
  • Nanotecnología

Sus antecedentes:

  • El desplazamiento de la cadena de ADN inspira nuevos métodos en nanotecnología.
  • El autoensamblaje polimérico ofrece rutas para nanoestructuras complejas.
  • La formación de complejos estereoscópicos es una interacción clave en algunos sistemas de polímeros.

Objetivo del estudio:

  • Para demostrar el intercambio de hebras helicoidales sintéticas en los complejos estereoscópicos de triple hélice de polimethacrilato (PMMA).
  • Explorar la utilidad y la robustez de este mecanismo de intercambio de hebras helicoidales.
  • Para crear nanosistemas poliméricos dinámicos con morfologías sintonizables.

Principales métodos:

  • Preparación de copolímeros de bloque estereorregulados de PMMA y polietileno glicol (PEG).
  • Utilizando el autoensamblaje impulsado por la cristalización a través de la formación de complejos estereoscópicos.
  • Formación de micelas con morfologías esféricas o parecidas a gusanos mediante el ajuste del peso molecular.

Principales resultados:

  • Demostración exitosa del intercambio de hebras helicoidales de PMMA.
  • Se logró un cambio reversible de las morfologías de las micelas (esféricas/similares a gusanos).
  • El proceso era robusto y ajustable basado en la composición de copolímero.

Conclusiones:

  • El intercambio de hebras helicoidales en los estereocomplejos de PMMA es un mecanismo viable para la programación dinámica de materiales.
  • Este enfoque permite la creación de nanosistemas "inteligentes" receptivos y adaptables.
  • Los hallazgos ofrecen rutas de síntesis escalables para nanomateriales poliméricos avanzados.