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Se requieren células T que expresan colina acetiltransferasa para controlar la infección viral crónica
Maureen A Cox1, Gordon S Duncan1, Gloria H Y Lin1
1The Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada.
Science (New York, N.Y.)
|February 9, 2019
Resumen
La producción de acetilcolina derivada de las células T, regulada por la colina acetiltransferasa (ChAT), es crucial para la inmunidad antiviral. La deficiencia de ChAT en las células T compromete la migración de las células inmunes y el control viral durante la infección.
Área de la Ciencia:
- Inmunología
- La neurociencia
- Virología
Sus antecedentes:
- La acetilcolina (ACh) es conocida como un neurotransmisor.
- El papel del ACh derivado de las células T en la inmunidad está emergiendo.
- La función de la ACh derivada de los linfocitos en las infecciones virales sigue sin estar clara.
Objetivo del estudio:
- Investigar el papel de la acetilcolina derivada de las células T (ACh) en las infecciones virales.
- Para aclarar el mecanismo de la producción de ACh en las células T durante el desafío viral.
Principales métodos:
- Se estudió la infección por el virus de la coriomeningitis linfocítica (LCMV) en ratones.
- Se analizó la inducción de la colina acetiltransferasa (ChAT) en las células T CD4+ y CD8+.
- Se utilizaron modelos de eliminación específicos de las células T.
- Se evaluó la migración de células T, la vasodilatación y el control viral.
Principales resultados:
- La colina acetiltransferasa (ChAT) fue inducida significativamente en las células T durante la infección por LCMV, dependiendo de la IL-21.
- La deleción específica de las células T de Chat alteró la vasodilatación y la migración de células T antivirales a los tejidos infectados.
- La pérdida de ChAT en las células T resultó en un control comprometido de la infección crónica por LCMV.
Conclusiones:
- Demostró un papel crítico para el ChAT en las células T durante la infección viral.
- Se identificó una nueva vía que involucra ACh derivado de células T que apoya la migración y la inmunidad de las células T antivirales.
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