Video Experimental Relacionado
Updated: Jan 29, 2026
12:02
An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity
Published on: November 2, 2016
12.6K
Monómeros aromáticos fluorados como bloques de construcción para controlar la conformación y la estructura del
Diana Gimenez1, Guangfeng Zhou2, Matthew F D Hurley2
1Department of Chemistry , Durham University , South Road , Durham DH1 3LE , U.K.
Journal of the American Chemical Society
|February 12, 2019
Resumen
Los nuevos monómeros que contienen flúor ofrecen control sobre la conformación de los peptoides al influir en el equilibrio cis/trans. Estos avances en el diseño de peptoides (peptidomiméticos) son cruciales para el desarrollo de fármacos y biomateriales.
Área de la Ciencia:
- Química de los polímeros
- Química orgánica
- Ciencias de los materiales
Sus antecedentes:
- Los peptoides, una clase de peptidomiméticos, son valiosos en el desarrollo de fármacos y biomateriales.
- El logro de estructuras secundarias estables en peptoides es difícil debido a los desafíos en el control del equilibrio cis/trans de la amida terciaria.
Objetivo del estudio:
- Desarrollar nuevos monómeros aromáticos que contengan flúor para un control preciso de la conformación peptoide.
- Investigar el papel de los sustituyentes del flúor en la influencia del equilibrio de la amida terciaria peptoide cis/trans.
Principales métodos:
- Síntesis de nuevos monómeros aromáticos que contienen flúor.
- Incorporación de estos monómeros en las cadenas peptoides.
- Análisis de la conformación de los peptoides y de las proporciones de isómeros cis/trans.
Principales resultados:
- Se demostró que un grupo de fluoropiridina puede controlar la conformación peptoide sin requerir quiralidad monomérica.
- Se demostró que un grupo trifluoro-metilo (NCFRpe) aumenta significativamente la preferencia del isómero cis en comparación con un grupo metilo (NRpe) en 5 veces.
- Se estableció un método para controlar eficazmente el equilibrio cis/trans de la amida terciaria peptoide.
Conclusiones:
- Los monómeros aromáticos que contienen fluor proporcionan una herramienta poderosa para el diseño de estructuras secundarias peptoides.
- Estos hallazgos avanzan en el desarrollo de peptoides para aplicaciones en el descubrimiento de fármacos y biomateriales avanzados.
- La capacidad de controlar el isomerismo cis/trans es clave para adaptar las propiedades de los peptoides.
Videos de Conceptos Relacionados
01:13Electrophilic Aromatic Substitution: Fluorination and Iodination of Benzene
7.5K
Bromination and chlorination of aromatic rings by electrophilic aromatic substitution reactions are easily achieved, but fluorination and iodination are difficult to achieve. Fluorine is so reactive that its reaction with benzene is difficult to control, resulting in poor yields of monofluoroaromatic products. To address this, Selectfluor reagent is used as a fluorine source in which a fluorine atom is bonded to a positively charged nitrogen.
7.5K
01:20Conformity
48.2K
Conformity is the change in a person’s behavior to go along with the group, even if that person does not agree with the group.
48.2K
01:18Aromatic Hydrocarbon Anions: Structural Overview
3.7K
Neutral hydrocarbons like cyclopentadiene with an odd number of carbon atoms and one intervening CH2 group in the ring are not aromatic. Cyclopentadiene with 4 π electrons does not satisfy the 4n + 2 π electron rule. Additionally, the intervening CH2 group is sp3 hybridized and lacks a vacant p orbital, thereby interrupting the overlap of p orbitals in a continuous manner and preventing the delocalization of π electrons throughout the ring.
Due to the absence of continuous...
Due to the absence of continuous...
3.7K
01:18Aromatic Hydrocarbon Cations: Structural Overview
3.8K
Cycloheptatriene is a neutral monocyclic unsaturated hydrocarbon that consists of an odd number of carbon atoms and an intervening sp3 carbon in the ring. The three double bonds in the ring correspond to 6 π electrons, which is a Huckel number, and therefore satisfies the criteria of 4n + 2 π electrons. However, the intervening sp3 carbon disrupts the continuous overlap of p orbitals. As a result, cycloheptatriene is not aromatic.
Removing one hydrogen from the intervening CH2 group...
Removing one hydrogen from the intervening CH2 group...
3.8K
02:15Protein and Protein Structure
87.4K
Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme...
A protein's shape is critical to its function. For example, an enzyme...
87.4K
02:20Conformations of Butane
18.0K
Unlike ethane and propane that have only two major conformations, butane has more than two conformers. The staggered form of butane in which the bulky methyl groups on the two carbons are placed on opposite sides, that is, at a dihedral angle of 180°, is the lowest energy, most stable form — called the anti conformer. This conformation is stabilized due to the absence of steric repulsion between the largely spaced out methyl groups. The other two staggered conformations are...
18.0K