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El sueño modula la hematopoyesis y protege contra la aterosclerosis
Cameron S McAlpine1, Máté G Kiss1,2,3, Sara Rattik1
1Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Nature
|February 15, 2019
Resumen
La interrupción del sueño eleva el riesgo de enfermedades cardiovasculares al alterar la producción de células inmunes. Este estudio revela un eje neuroinmune que vincula el sueño, la formación de células sanguíneas y la protección contra la aterosclerosis en ratones.
Área de la Ciencia:
- La neurociencia
- Inmunología
- Ciencias cardiovasculares
Sus antecedentes:
- El sueño es crucial para la salud, y el sueño interrumpido está relacionado con enfermedades cardiovasculares.
- Los mecanismos celulares y moleculares específicos que conectan el sueño con la salud cardiovascular no se comprenden bien.
Objetivo del estudio:
- Investigar cómo el sueño regula la hematopoyesis (formación de células sanguíneas) y protege contra la aterosclerosis en un modelo de ratón.
- Para identificar las vías neuroinmunes involucradas en los efectos protectores cardiovasculares del sueño.
Principales métodos:
- La fragmentación del sueño fue inducida en ratones.
- Se midieron los niveles de células inmunes específicas (monocitos altos en Ly-6C), el tamaño de la lesión aterosclerótica y la hipocretina del neuropéptido.
- Las modificaciones genéticas y la suplementación con hipocretina se utilizaron para explorar las relaciones causales.
Principales resultados:
- La fragmentación del sueño aumentó los monocitos altos en Ly-6C y exacerbó la aterosclerosis en ratones.
- Se observaron niveles reducidos de hipocretina en ratones con sueño fragmentado.
- La modulación de la señalización de hipocretina o los niveles de CSF1 en las células hematopoyéticas mejoraron los efectos de la fragmentación del sueño en los monocitos y la aterosclerosis.
Conclusiones:
- El sueño regula la hematopoiesis y protege contra la aterosclerosis a través de un eje neuroinmune que involucra a la hipocretina.
- Este eje conecta el cerebro (hipocretina) con el sistema inmunológico (producción de monocitos) y la salud cardiovascular.
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