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Visión de imágenes en el infrarrojo cercano de mamíferos a través de nanoantenas retinianas inyectables y
Yuqian Ma1, Jin Bao2, Yuanwei Zhang3
1Hefei National Laboratory for Physical Sciences at the Microscale, Neurodegenerative Disorder Research Center, CAS Key Laboratory of Brain Function and Disease, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230026, China.
Cell
|March 5, 2019
Resumen
Los científicos desarrollaron nanopartículas inyectables que permiten a los ratones ver la luz del infrarrojo cercano (NIR), un espectro invisible para los mamíferos. Este avance permite la visión paralela con la luz del día, abriendo nuevas posibilidades de dispositivos bio-integrados.
Área de la Ciencia:
- Oftalmología
- Nanotecnología
- La neurociencia
Sus antecedentes:
- Los mamíferos están limitados a ver la luz visible (por debajo de 700 nm) debido a las propiedades de la opsina.
- La detección de luz invisible en el infrarrojo cercano (NIR) es un desafío tecnológico y biológico significativo.
- Los métodos existentes para la detección NIR carecen de integración biológica y a menudo son invasivos.
Objetivo del estudio:
- Desarrollar un método que permita a los mamíferos percibir la luz NIR.
- Para crear un sistema bio-integrado para la visión NIR con efectos secundarios mínimos.
- Explorar el potencial de las nanopartículas de upconversion para el aumento visual.
Principales métodos:
- Desarrollo de nanopartículas de conversión ascendente inyectables a los fotorreceptores (pbUCNP).
- Anclaje de pbUCNP en los fotorreceptores de la retina para actuar como transductores de luz NIR.
- Utilizando grabaciones de un solo fotorreceptor, electrorretinogramas, grabaciones corticales y pruebas de comportamiento visual en ratones.
Principales resultados:
- Los ratones inyectados con pbUCNP demostraron la capacidad de percibir la luz NIR.
- Los ratones tratados podían diferenciar patrones de luz NIR y formas NIR sofisticadas.
- La visión NIR era compatible con la luz ambiental diurna y funcionaba en paralelo con la visión nativa.
Conclusiones:
- Los pbUCNP inyectables crean con éxito una visión de imagen de luz NIR funcional en mamíferos.
- Esta tecnología ofrece un nuevo enfoque para el aumento visual y los nanodispositivos biointegrados.
- El método presenta una forma segura y eficaz de superar las limitaciones visuales naturales.
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