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Un origen embrionario común de las células madre impulsa el desarrollo y la neurogénesis adulta
Daniel A Berg1, Yijing Su1, Dennisse Jimenez-Cyrus2
1Department of Neuroscience and Mahoney Institute for Neurosciences, University of Pennsylvania, Philadelphia, PA 19104, USA.
Cell
|April 2, 2019
Resumen
Las células madre neurales adultas, conocidas como progenitores Hopx+, generan continuamente nuevas neuronas durante toda la vida. Este estudio rastrea sus orígenes embrionarios y su función de por vida en el hipocampo del ratón.
Área de la Ciencia:
- La neurociencia
- Biología del desarrollo
- La genética
Sus antecedentes:
- Los progenitores neurales adultos generan nuevas neuronas durante toda la vida en regiones específicas del cerebro.
- El origen embrionario y el establecimiento de estos progenitores neurales adultos siguen siendo poco conocidos.
Objetivo del estudio:
- Investigar los orígenes embrionarios y la trayectoria de desarrollo de los progenitores neurales adultos.
- Para aclarar los mecanismos moleculares y epigenéticos que rigen la neurogénesis dentada.
Principales métodos:
- Se utilizó el rastreo del precursor Hopx+ en ratones embrionarios (día 11.5).
- Se realizó la secuenciación de ARN (RNA-seq) y la secuenciación de ATAC (ATAC-seq) en progenitores neurales.
- Populaciones progenitoras analizadas durante las etapas embrionaria, postnatal temprana y adulta.
Principales resultados:
- Se han identificado precursores Hopx+ que dan lugar a progenitores proliferativos que generan neuronas granulares.
- Se demostró una transición de estos progenitores en células gliales radiales en reposo después del parto.
- Reveló firmas moleculares y epigenéticas conservadas a través de etapas de desarrollo.
Conclusiones:
- Apoyó un modelo "continuo" de neurogénesis dentada desde un solo grupo progenitor.
- La neurogénesis adulta en el giro dentado es una extensión de por vida de los procesos de desarrollo.
- Esta neurogénesis continua probablemente mantiene la plasticidad del hipocampo.
Palabras clave:
- ¿Qué es eso?desarrollo del cerebroPerfilado del paisaje de la cromatinaGiro dentadoperfiles de expresión génicaEl hipocampoEl rastreo del linajecélulas madre neuralesneurogénesisMás Videos Relacionados
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