Video Experimental Relacionado
Updated: Jul 9, 2026

09:27
New Tools to Expand Regulatory T Cells from HIV-1-infected Individuals
Published on: May 30, 2013
El gen T4 codifica el receptor del virus del SIDA y se expresa en el sistema inmunológico y el cerebro
Cell
|November 7, 1986
Resumen
La proteína T4 humana en las superficies celulares permite la infección por el virus del SIDA mediante la mediación de la unión específica y la internalización. Esta proteína T4 es la proteína T4.
Área de la Ciencia:
- Inmunología Inmunología.
- Virología Virología.
- Biología Molecular Biología Molecular
Sus antecedentes:
- La patogénesis del Síndrome de Inmunodeficiencia Adquirida (SIDA) incluye retrovirus humanos.
- La proteína T4, un marcador superficial en los linfocitos, juega un papel en las interacciones celulares.
Objetivo del estudio:
- Para investigar el papel de la proteína T4 en la patogénesis del SIDA.
- Para aclarar el mecanismo de entrada del virus del SIDA en las células.
Principales métodos:
- Aislamiento de clones que codifican la proteína T4 humana.
- Expresión del gen T4 en varios entornos celulares.
- Demostración de la interacción del virus del SIDA con las moléculas de T4.
Principales resultados:
- El virus del SIDA interactúa específicamente con las moléculas T4 en los linfocitos y las células epiteliales.
- La presencia de T4 hace que las células sean susceptibles a la infección por el virus del SIDA.
- El complejo del virus T4-AIDS se internaliza a través de la endocitosis mediada por el receptor.
- La expresión del gen T4 en el cerebro y las células linfoides explica el doble tropismo del virus.
Conclusiones:
- La proteína T4 es crucial para la entrada celular y la patogénesis del virus del SIDA.
- El virus del SIDA explota la proteína T4 para atacar a las células T4+, incluidas las del cerebro y los tejidos linfoides.
Videos de Conceptos Relacionados
Enzyme-linked Receptors
Enzyme-linked receptors are proteins that act as both receptor and enzyme, activating multiple intracellular signals. This is a large group of receptors that include the receptor tyrosine kinase (RTK) family. Many growth factors and hormones bind to and activate the RTKs.
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
Retrovirus Life Cycles
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the retrovirus to...
Diversity of Antigen Receptors
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
T Cell Activation and Clonal Selection
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
T Cell Types and Functions
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Sexually Transmitted Infections
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...

