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Updated: Jan 26, 2026

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Las proteínas UIM de unión a ATG8 definen una nueva clase de adaptadores y receptores de autofagia

Richard S Marshall1, Zhihua Hua2, Sujina Mali1

  • 1Department of Biology, Washington University in St. Louis, St. Louis, MO 63130, USA.

Cell
|April 9, 2019
PubMed
Resumen

Los investigadores descubrieron una nueva clase de proteínas que se unen a ATG8 / LC3 durante la autofagia utilizando secuencias similares al motivo de interacción con la ubiquitina (UIM). Este hallazgo amplía la comprensión de la autofagia selectiva e identifica nuevos reguladores de la dinámica de las vesículas autofágicas.

Palabras clave:
AIM (en inglés)Grupo de trabajo ATG8Motivo de interacción con el ATG8Los ejemplares de ArabidopsisCDC48/p97 En el caso de lasRegión de interacción LC3Las LDSLIR (en inglés)Sitio de acoplamiento LIR/AIMSistema de gestión de las emisionesLa UIMSitio de acoplamiento UIMLa autofagiaMotivo de interacción con la ubiquitinalevadura y levadura

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