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Múltiples antepasados denisovanos profundamente divergentes en los papúes
Guy S Jacobs1, Georgi Hudjashov2, Lauri Saag3
1Complexity Institute, Nanyang Technological University, Singapore 637723, Singapore.
Cell
|April 15, 2019
Resumen
Los humanos modernos se cruzaron con varios grupos de denisovanos, no sólo uno. El análisis del ADN antiguo revela linajes denisovanos distintos en los papúes y los asiáticos orientales, lo que indica interacciones complejas de homínidos arcaicos.
Área de la Ciencia:
- La evolución del hombre
- La paleogenética
- Genética de las poblaciones
Sus antecedentes:
- Se conocen las secuencias del genoma de los neandertales y los denisovanos.
- Los homínidos arcaicos se cruzaron con los humanos modernos que se dispersaron desde África.
Objetivo del estudio:
- Para investigar el ADN arcaico en las poblaciones modernas de la isla del sudeste asiático y Nueva Guinea.
- Determinar el origen y la complejidad de la introgresin de los homínidos arcaicos.
Principales métodos:
- Análisis de 161 nuevos genomas de las islas del sudeste asiático y Nueva Guinea.
- Identificación de haplotipos arcaicos de alta confianza.
- Comparación con los genomas de homínidos arcaicos conocidos.
Principales resultados:
- Se identificaron haplotipos arcaicos de alta confianza en 161 nuevos genomas.
- Los papúes modernos llevan variantes genéticas de dos linajes denisovanos profundamente divergentes.
- Un tercer linaje denisovano se encontró en los asiáticos orientales modernos.
Conclusiones:
- La introgresión involucró múltiples grupos geográficamente aislados de denisovanos.
- Los linajes denisovanos se separaron hace más de 350.000 años.
- El contacto con los homínidos arcaicos era complejo, con variaciones regionales.
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