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Updated: Jan 25, 2026

A BW Reporter System for Studying Receptor-Ligand Interactions
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Bases estructurales del reconocimiento de ligandos en el receptor de melatonina MT1 humano

Benjamin Stauch1,2, Linda C Johansson1,2, John D McCorvy3,4

  • 1Bridge Institute,USC Michelson Center for Convergent Biosciences, University of Southern California, Los Angeles, CA, USA.

Nature
|April 26, 2019
PubMed
Resumen

Determinamos las estructuras del receptor de melatonina 1 (MT1) vinculado a los medicamentos para el insomnio y los agonistas. Estos hallazgos revelan mecanismos únicos de entrada de ligandos e interacciones aromáticas, ayudando al diseño futuro de fármacos para trastornos del ritmo circadiano.

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