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Generación controlada por luz de oxígeno singlete dentro de un ciclo metálico discreto de doble etapa para la terapia del cáncer

  • 0Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering , East China Normal University , Shanghai 200062 , PR China.
Journal of the American Chemical Society +

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16 de mayo de 2019

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16 de mayo de 2019

Ver abstracta en PubMed

Resumen

Este resumen es generado por máquina.

Los investigadores desarrollaron un nuevo ciclo metálico que permite la generación controlada y reversible de oxígeno singlete (1O2) para la terapia fotodinámica. Este sistema con interruptor "apagado", entregado a través de nanopartículas, efectivamente ataca y elimina las células cancerosas con la activación de la luz.

Área De La Ciencia

  • Química supramolecular
  • Ciencias de los materiales
  • Nanotecnología

Sus Antecedentes

  • El control no invasivo de la generación de oxígeno (1O2) es crucial para la terapia fotodinámica.
  • Los métodos existentes a menudo carecen de un control espacio-temporal preciso sobre la producción de 1O2.

Objetivo Del Estudio

  • Desarrollar un ciclo metálico de dos etapas para la conmutación "off-on" de la generación de 1O2.
  • Para crear un sistema de entrega basado en nanopartículas para la terapia dirigida contra el cáncer.

Principales Métodos

  • Sintetizó un ciclo metálico de dos etapas usando bloques de construcción de fotosensibilizadores y conmutadores fotocrómicos.
  • Las nanopartículas cargadas de metales formuladas para la entrega celular.
  • Se ha investigado la generación de 1O2 y la citotoxicidad de las células cancerosas in vitro e in vivo.

Principales Resultados

  • El ciclo metálico exhibió un cambio reversible de "apagado" de la generación de 1O2 a través de la transferencia de energía intramolecular.
  • Las nanopartículas de ciclo metálico demostraron una entrega eficiente a las células cancerosas.
  • Las nanopartículas de anillo abierto activadas por la luz mostraron una citotoxicidad significativamente mayor para las células cancerosas en comparación con las contrapartes de anillo cerrado.
  • Se logró una eliminación eficaz del tumor in vivo con la generación de 1O2 controlada por luz.

Conclusiones

  • Los complejos de coordinación supramolecular con estados de doble etapa ofrecen una nanoplataforma versátil para la generación controlada de 1O2.
  • El sistema desarrollado muestra una promesa significativa para el tratamiento no invasivo del tumor.
  • Este enfoque permite una regulación precisa del 1O2 para aplicaciones teranosticas avanzadas.

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