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Los ácidos grasos aumentan la inmunidad innata
Allison C Billi1, Johann E Gudjonsson1
1Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Cell
|May 18, 2019
Resumen
Los ácidos grasos elevados desencadenan la inmunidad innata y la inflamación al alterar el metabolismo celular. Este cambio metabólico, que involucra cambios de glucólisis y fosforilación oxidativa, vincula las dietas altas en grasas con enfermedades inflamatorias sistémicas.
Área de la Ciencia:
- Adaptación metabólica
- Inmunología
- La inflamación
Sus antecedentes:
- Las dietas altas en grasas están relacionadas con enfermedades inflamatorias sistémicas.
- Los mecanismos precisos que conectan los ácidos grasos de la dieta con la inflamación no se comprenden completamente.
Objetivo del estudio:
- Investigar los mecanismos por los que los ácidos grasos inducen la inmunidad innata y la inflamación.
- Identificar las adaptaciones metabólicas en respuesta al aumento de los ácidos grasos.
Principales métodos:
- Análisis de las vías metabólicas, incluida la glucólisis y la fosforilación oxidativa.
- Investigación de la respuesta de las proteínas desplegadas (UPR).
Principales resultados:
- Los ácidos grasos elevados inducen un cambio metabólico que favorece la glucólisis sobre la fosforilación oxidativa.
- Se observa la activación de la respuesta proteica desplegada en respuesta a altos niveles de ácidos grasos.
- Estos cambios vinculan las dietas occidentales altas en grasas con enfermedades inflamatorias sistémicas.
Conclusiones:
- La reprogramación metabólica inducida por los ácidos grasos es un factor clave de la activación inmune innata y la inflamación.
- Comprender estas vías puede ofrecer objetivos terapéuticos para enfermedades inflamatorias asociadas con la dieta.
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