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Piwi/PRG-1 Argonauta y TGF-β Median la Evitación Patógena Aprendida Transgeneracional
Rebecca S Moore1, Rachel Kaletsky1, Coleen T Murphy1
1Department of Molecular Biology & LSI Genomics, Princeton University, Princeton, NJ 08544, USA.
Cell
|June 11, 2019
Resumen
La evitación aprendida de bacterias patógenas en C. elegans se hereda a través de generaciones a través de la transmisión germinal. Esta herencia epigenética transgeneracional, dependiente de PRG-1 y DAF-7, mejora la supervivencia de la progenie.
Área de la Ciencia:
- La epigenética
- Neurociencia del comportamiento
- Biología del desarrollo
Sus antecedentes:
- La herencia de comportamientos aprendidos puede proporcionar ventajas evolutivas para la supervivencia de la descendencia.
- Las exposiciones ambientales pueden inducir cambios hereditarios en la expresión génica.
Objetivo del estudio:
- Para investigar la herencia transgeneracional del comportamiento de evitación aprendido en Caenorhabditis elegans.
- Para identificar los mecanismos moleculares que subyacen a este comportamiento heredado.
Principales métodos:
- Ensayos conductuales para evaluar la evitación aprendida de Pseudomonas aeruginosa (PA14).
- Análisis genético utilizando mutantes de C. elegans para el PRG-1 y el DAF-7.
- Análisis de la expresión génica en las neuronas sensoriales (ASI) y la línea germinal.
Principales resultados:
- La progenie de C. elegans heredó el comportamiento de evitación de PA14 durante hasta cuatro generaciones.
- Esta herencia requería el ligando TGF-β DAF-7 en las neuronas ASI y el componente de la vía Piwi PRG-1.
- La evitación heredada confería una ventaja de supervivencia frente al PA14, dependiente del PRG-1.
Conclusiones:
- La herencia epigenética transgeneracional de la evitación de patógenos aprendida es posible en C. elegans.
- Este mecanismo, que involucra a DAF-7 y PRG-1, optimiza la supervivencia de la descendencia en entornos peligrosos.
- La herencia epigenética de los comportamientos aprendidos puede ser una estrategia adaptativa clave en condiciones fluctuantes.
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