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Evolución adaptativa en las lisozimas estomacales de los fermentadores del intestino previo
C B Stewart1, J W Schilling, A C Wilson
1Department of Biochemistry, University of California, Berkeley 94720.
Nature
|November 2, 1987
Resumen
La evolución convergente en los mamíferos condujo a las lisozimas estomacales en las vacas y los languros. La lisozima de Langur evolucionó rápidamente, lo que sugiere que la selección darwiniana positiva impulsó su adaptación para la digestión.
Área de la Ciencia:
- Biología evolutiva Biología evolutiva.
- La bioquímica es la bioquímica.
- Los sistemas digestivos de los mamíferos.
Sus antecedentes:
- Evolución convergente de los forrajes fermentativos en los mamíferos.
- Reclutamiento de lisozima como enzima bacteriolítica estomacal en rumiantes (por ejemplo, vacas) y monos colobinos (por ejemplo, langurs).
- Las propiedades fisicoquímicas y catalíticas compartidas de las lisozimas estomacales sugieren una adaptación a los entornos gástricos.
Objetivo del estudio:
- Investigar la base molecular de las propiedades compartidas de los lisozimas estomacales.
- Determinar la trayectoria evolutiva y las presiones de selección en la lisozima del estómago del langur.
Principales métodos:
- Secuenciación de la lisozima del estómago de langur.
- Análisis del árbol filogenético comparando la lisozima langur con otras lisozimas conocidas.
- Análisis comparativo de la secuencia y las propiedades funcionales.
Principales resultados:
- La secuencia de lisozima de Langur muestra similitud con la lisozima del estómago de la vaca.
- La lisozima de Langur evolucionó aproximadamente el doble de rápido que otras lisozimas de primates.
- La evidencia sugiere convergencia funcional y de secuencia entre los lisozimas del langur y el estómago de la vaca.
Conclusiones:
- La selección darwiniana positiva probablemente impulsó una evolución significativa de la lisozima del estómago del langur.
- La evolución convergente de la lisozima estomacal destaca la evolución adaptativa de las proteínas en respuesta a los cambios en la dieta.
- El estudio proporciona información sobre los mecanismos moleculares subyacentes a la adaptación en las enzimas digestivas.
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