Video Experimental Relacionado
Updated: Jan 23, 2026
11:32
Evaluating Cell Death Signaling by Immunofluorescence in a Rat Model of Ischemic Stroke
Published on: January 3, 2025
1.6K
S100a8/a9 La señalización causa disfunción mitocondrial y muerte de los cardiomiocitos en respuesta a una lesión
Yulin Li1, Boya Chen1, Xinying Yang1
1Beijing Anzhen Hospital of Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Diseases, China (Y. Li, B.C., Z.Y., C.Z., Y.J., P.L., Y. Liu, Z.L., B.Q., J.D.).
Circulation
|June 22, 2019
Resumen
La lesión por isquemia-reperfusión miocárdica (IM/R) es una condición crítica. Este estudio identifica a S100a8/a9 como un mediador clave de la lesión MI/R, ofreciendo un objetivo terapéutico potencial para la recuperación del ataque cardíaco.
Área de la Ciencia:
- Investigación cardiovascular
- La medicina molecular
- Proteómica y genómica
Sus antecedentes:
- La lesión de isquemia-reperfusión miocárdica (IM/R) plantea un desafío clínico significativo con opciones terapéuticas limitadas.
- Los enfoques omicos imparciales son cruciales para la identificación de nuevos mediadores de la lesión MI/R.
Objetivo del estudio:
- Identificar los mediadores tempranos de la lesión MI/R mediante el análisis dinámico del transcriptoma.
- Para aclarar el papel y el mecanismo de S100a8 / a9 en la lesión de MI / R.
- Investigar la relevancia clínica de S100a8/ a9 en pacientes con infarto agudo del miocardio.
Principales métodos:
- Análisis dinámico del transcriptoma de los corazones de ratones sometidos a MI/R.
- Estudios de pérdida de función y ganancia de función de S100a8/a9.
- Medición de los niveles séricos de S100a8/ a9 en pacientes con infarto de miocardio después de la ICP y seguimiento de eventos cardiovasculares adversos importantes.
Principales resultados:
- S100a8 / a9 fue identificado como el gen más regulado durante la reperfusión temprana.
- S100a9 knockout mejoró la función cardíaca, mientras que la sobreexpresión empeoró la lesión.
- S100a8/ a9 indujo la disfunción mitocondrial mediante la inhibición del complejo I a través de la señalización TLR4/ ERK/ PPARGC1A/ NRF1.
- S100a9 El tratamiento con anticuerpos neutralizantes redujo la lesión de MI/R.
- Los niveles séricos elevados de S100a8/ a9 después de la ICP en pacientes con infarto de miocardio se correlacionaron con eventos cardiovasculares adversos.
Conclusiones:
- S100a8/ a9 es un regulador crítico de la muerte de los cardiomiocitos en la lesión temprana de MI/ R mediante la supresión de la función mitocondrial.
- La orientación de la señalización mediada por S100a8/a9 presenta una nueva estrategia terapéutica prometedora para la lesión de IM/R.
Videos de Conceptos Relacionados
01:22Diversity in Cell Signaling Responses
7.7K
The physiological function of a cell and cellular communication are outcomes of a range of extrinsic signals, intracellular signaling pathways, and cellular responses. No two cell types express the same repertoire of signaling components. Receptors are highly selective for their cognate ligands, but once activated, they can alter multiple cellular processes such as DNA transcription, protein synthesis, and metabolic activity.
Graded and Abrupt Responses
Some signaling systems generate...
Graded and Abrupt Responses
Some signaling systems generate...
7.7K
02:59Animal Mitochondrial Genetics
9.0K
Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
9.0K
02:16Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes
15.4K
The present-day mitochondrial and chloroplast genomes have retained some of the characteristics of their ancestral prokaryotes and also have acquired new attributes during their evolution within eukaryotic cells. Like prokaryotic genomes, mitochondrial and chloroplast genomes neither bind with histone-like proteins nor show complex packaging into chromosome-like structures, as observed in eukaryotes. Unlike mitotic cell divisions observed in eukaryotic cells, mitochondria and chloroplasts...
15.4K
02:19Export of Mitochondrial and Chloroplast Genes
4.1K
A eukaryotic cell can have up to three different types of genetic systems: nuclear, mitochondrial, and chloroplast. During evolution, organelles have exported many genes to the nucleus; this transfer is still ongoing in some plant species. Approximately 18% of the Arabidopsis thaliana nuclear genome is thought to be derived from the chloroplast’s cyanobacterial ancestor, and around 75% of the yeast genome derived from the mitochondria’s bacterial ancestor. This export has occurred...
4.1K
02:03What is Cell Signaling?
129.9K
Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate to respond to the environment.
129.9K
01:21Paracrine Signaling
59.5K
Paracrine signaling allows cells to communicate with their immediate neighbors via secretion of signaling molecules. Such a signal can only trigger a response in nearby target cells because the signal molecules degrade quickly or are inactivated if not taken up. Prominent examples of paracrine signaling include nitric oxide signaling in blood vessels, synaptic signaling of neurons, the blood clotting system, tissue repair/wound healing, and local allergic skin reactions. Nitric oxide as a...
59.5K