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A Functional Assay for Gap Junctional Examination; Electroporation of Adherent Cells on Indium-Tin Oxide

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Published on: October 18, 2014

Estructura y Función de un Análogo de Junción de Vacío Bacteriano

Gregor L Weiss¹, Ann-Katrin Kieninger², Iris Maldener²

¹Department of Biology, Institute of Molecular Biology & Biophysics, Eidgenössische Technische Hochschule Zürich, Otto-Stern-Weg 5, 8093 Zürich, Switzerland.

|July 13, 2019

Resumen

Las cianobacterias multicelulares utilizan las uniones septales para la comunicación celular. El estrés hace que estas uniones se cierren de manera reversible, controlando el intercambio molecular y la diferenciación celular.

Palabras clave:

conexiones célula-célula Las cianobacterias criotomografía por electrones Recuperación de la fluorescencia después del fotoblanqueamiento Tráfico de membranas Multicelularidad las uniones septales Medición del subtomograma

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Área de la Ciencia:

Microbiología
Biología celular
Biología estructural

Sus antecedentes:

La multicelularidad depende de las conexiones entre células para la comunicación y la diferenciación.
Las uniones septales en las cianobacterias son cruciales para el intercambio molecular intercelular, pero su estructura y función son poco conocidas.

Objetivo del estudio:

Para aclarar la arquitectura in situ de las uniones del tabique cianobacteriano.
Investigar el papel de las uniones septal en el control de la comunicación intercelular bajo estrés.

Principales métodos:

Criotomografía de electrones de filamentos cianobacterianos triturados con haz de iones criogenizados.
Recuperación de la fluorescencia después del foto blanqueamiento (FRAP) para evaluar la comunicación intercelular.

Principales resultados:

Las uniones del septo forman un tubo a través del peptidoglicano, con tapones y tapas citoplasmáticas que contienen FraD en cada extremo.
La comunicación intercelular está bloqueada bajo condiciones de estrés.
El encierro inducido por estrés implica un cambio conformacional reversible en la tapa de unión septal.

Conclusiones:

El estudio revela la estructura detallada de las uniones del tabique cianobacteriano, proporcionando un marco mecanicista para su función.
Estas antiguas uniones celulares exhiben un mecanismo cerrado para controlar el intercambio molecular, conservado a lo largo de la vida.
Este mecanismo de entrada es esencial para regular la diferenciación celular en los organismos multicelulares.