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Las nanoestructuras brillantes de G-cuadruplex funcionan con linternas de porfirina
Pravin Pathak1, Wei Yao1, Katherine Delaney Hook2
1Department of Chemistry , Tulane University , 2015 Percival Stern Hall , New Orleans , Louisiana 70118 , United States.
Journal of the American Chemical Society
|July 20, 2019
Resumen
Los investigadores desarrollaron un método de "conexión y máscara" para crear nanomateriales de colorante brillantes y densamente empacados. Esta estrategia evita la agregación de colorantes, mejorando la fluorescencia para aplicaciones fotónicas.
Área de la Ciencia:
- Química supramolecular
- Nanotecnología
- Materiales fotónicos
Sus antecedentes:
- La disposición densa de cromóforos en andamios a nanoescala permite aplicaciones fotónicas.
- El autoensamblaje de ADN de secuencias aplicadas con tinte ofrece arquitecturas fotónicas programadas.
- Los desafíos incluyen el ensamblaje comprometido del ADN y los sistemas no fluorescentes debido a la agregación de colorantes.
Objetivo del estudio:
- Desarrollar una estrategia para crear nanomateriales de colorantes brillantes y densos utilizando el autoensamblaje acuoso.
- Para superar las limitaciones de la agregación de colorantes en las estructuras fotónicas basadas en ADN.
- Para permitir la fabricación ascendente de nuevos nanomateriales fluorescentes.
Principales métodos:
- Se empleó una estrategia de dos pasos de "atar y enmascarar".
- Se adjuntaron grandes tintes de porfirina a las secuencias de ADN formadoras de G-cuadruplex.
- Las tapas de β-ciclodextrina per-O-metilada (PMβCD) se utilizaron para enmascarar los tintes de porfirina, formando sintones supramoleculares.
- Estas secuencias enmascaradas de porfirina-ADN (PL-ADN) se autoensamblaron en arquitecturas cíclicas y cables G.
Principales resultados:
- La estrategia de "tenedor y máscara" creó con éxito estados de linterna de porfirina enmascarada (PL).
- Secuencias de PL-ADN autoensambladas en arquitecturas cíclicas y alambres G con cientos de tintes de porfirina.
- A pesar del embalaje denso (∼2 nm), los tintes de porfirina enmascarados exhibieron un brillo significativamente mejorado (hasta 180 veces).
- Las máscaras PMβCD impidieron la agregación π-π, preservando la fluorescencia del tinte.
Conclusiones:
- La estrategia de "conexión y máscara" es efectiva para crear nanomateriales de colorante brillantes y densamente empacados en solución acuosa.
- Este enfoque modular supera los problemas de agregación de tintes en los sistemas autoensamblados.
- El método proporciona una estrategia general para la fabricación ascendente de nanomateriales fluorescentes avanzados para aplicaciones fotónicas.
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