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Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model
Published on: April 6, 2022
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La evolución del uso del trasplante de microbiota fecal y las indicaciones terapéuticas emergentes
Jessica R Allegretti1, Benjamin H Mullish2, Colleen Kelly3
1Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
Lancet (London, England)
|August 6, 2019
Resumen
La secuenciación de alto rendimiento revela cambios en la microbiota intestinal en la enfermedad, pero la causalidad no está clara. El trasplante de microbiota fecal (FMT) es prometedor para restaurar la salud intestinal y tratar infecciones como C. difficile.
Área de la Ciencia:
- Microbiología
- La genómica
- Biología de sistemas
Sus antecedentes:
- La secuenciación de alto rendimiento y la biología de sistemas ofrecen información sobre el papel de la microbiota intestinal en la salud y la enfermedad.
- Se observan cambios distintivos en la composición y función de la microbiota intestinal en numerosas enfermedades, pero su relación causal sigue siendo incierta.
Objetivo del estudio:
- Explorar las posibles aplicaciones terapéuticas de la modulación de la microbiota intestinal.
- Destacar la creciente importancia del trasplante de microbiota fecal (TMF) en entornos clínicos y de investigación.
Principales métodos:
- Revisión de la comprensión actual de la microbiota intestinal en la salud y la enfermedad.
- Examen del trasplante de microbiota fecal como estrategia terapéutica.
Principales resultados:
- Actualmente se recomienda el trasplante de microbiota fecal para la infección recurrente por Clostridioides difficile.
- Numerosos ensayos clínicos están investigando la FMT para otras posibles indicaciones terapéuticas.
Conclusiones:
- El papel de la microbiota intestinal en la enfermedad requiere más investigación para establecer la causalidad.
- El trasplante de microbiota fecal representa un enfoque terapéutico prometedor para varias afecciones más allá de la infección por C. difficile.
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